Acido úrico ¿un nuevo factor contribuyente al desarrollo de obesidad?

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dc.contributor.authorValenzuela, Alex
dc.date.accessioned2018-01-02T13:36:26Z
dc.date.available2018-01-02T13:36:26Z
dc.date.issued2016
dc.description.abstractThe excess of uric acid is recognized as a risk factor for diverse metabolic diseases which include gout, urolithiasis, type 2 diabetes, arterial hypertension as well as metabolic syndrome and cardiovascular disease. Current studies suggest that the exaggerated increment in fructose consumption, caused mainly by added suggars, is implicated in the high prevalence of hyperuricemia in the western population.The loss of uricase by mutation of its gene 15 million years ago in the large hominids, including man, has contributed to hyperuricemia, facilitated through the metabolism of fructose the formation of uric acid. It has been proposed that the elevation of uric acid in the remote past was an evolutionary benefit to intensify the lipogenic effects of fructose, allowing humans to survive periods of fruit shortages. However, today the high consumption of fructose and resultant hyperuricemia are a disadvantage, increasing the development of obesity and type 2 diabetes.
dc.format.extent5
dc.identifier.citationRevista chilena de nutrición
dc.identifier.urihttp://hdl.handle.net/11447/1842
dc.identifier.urihttp://dx.doi.org/10.4067/S0717-75182016000300011
dc.language.isospa
dc.publisherSociedad Chilena de Nutrición, Bromatología y Toxicología
dc.subjectUricase
dc.subjectFructose
dc.subjectObesity
dc.subjectUric acid
dc.subjectHyperuricemia
dc.titleAcido úrico ¿un nuevo factor contribuyente al desarrollo de obesidad?
dc.title.alternativeUric acid: is it a new contributing factor to the development of obesity?
dc.typeArtículo

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