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Ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant staphylococcus aureus causing infective endocarditis

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dc.contributor.author Nigo, Masayuki
dc.contributor.author Diaz, Lorena
dc.contributor.author Carvajal, Lina P.
dc.contributor.author Tran, Truc T.
dc.contributor.author Rios, Rafael
dc.contributor.author Panesso, Diana
dc.contributor.author Garavito, Juan D
dc.contributor.author Miller, William
dc.contributor.author Wagner, Audrey
dc.date.accessioned 2017-08-30T13:40:54Z
dc.date.available 2017-08-30T13:40:54Z
dc.date.issued 2017
dc.identifier.citation Antimicrob Agents Chemother. 2017 Feb 23;61(3) es_CL
dc.identifier.uri http://dx.doi.org/10.1128/AAC.01235-16 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1620
dc.description.abstract We report a case of infective endocarditis (IE) caused by ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant S. aureus (MRSA). Resistance to ceftaroline emerged in the absence of drug exposure, and the E447K substitution in the active site of PBP2a previously associated with ceftaroline resistance was identified. Additionally, we present evidence of patient-to-patient transmission of the strain within the same unit. This case illustrates the difficulties in treating MRSA IE in the setting of a multidrug-resistant phenotype. es_CL
dc.format.extent 7 es_CL
dc.language.iso en_US es_CL
dc.publisher American Society for Microbiology es_CL
dc.subject Staphylococcus aureus es_CL
dc.subject ceftaroline es_CL
dc.subject endocarditis es_CL
dc.title Ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant staphylococcus aureus causing infective endocarditis es_CL
dc.type Artículo es_CL


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