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A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecali

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dc.contributor.author Munita, Jose
dc.contributor.author Tran, Truc
dc.contributor.author Diaz, Lorena
dc.contributor.author Panesso, Diana
dc.contributor.author Reyes, Jinnethe
dc.contributor.author Murray, Barbara
dc.contributor.author Arias, Cesar
dc.date.accessioned 2017-04-18T13:42:51Z
dc.date.available 2017-04-18T13:42:51Z
dc.date.issued 2013
dc.identifier.citation Antimicrob Agents Chemother. 2013 Jun;57(6):2831-3 es_CL
dc.identifier.uri http://dx.doi.org/10.1128/AAC.00021-13 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1164
dc.description.abstract The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy. es_CL
dc.format.extent 3 es_CL
dc.language.iso en_US es_CL
dc.publisher American Society for Microbiology es_CL
dc.subject Bacterial Proteins/genetics es_CL
dc.subject Codon/genetics es_CL
dc.subject Daptomycin/pharmacology es_CL
dc.subject Drug Resistance, Bacterial/genetics es_CL
dc.subject Enterococcus faecium/drug effects es_CL
dc.subject Sequence Deletion/genetics es_CL
dc.title A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecali es_CL
dc.type Artículo es_CL


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