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Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats

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dc.contributor.author Sasso, Corina
dc.contributor.author Santiano, Flavia
dc.contributor.author López-Fontana, Constanza
dc.contributor.author Pistone-Creydt, Virginia
dc.contributor.author Ezquer, Marcelo
dc.contributor.author Hapon, María
dc.contributor.author Jahn, Graciela
dc.contributor.author Carón, Rubén
dc.date.accessioned 2017-03-13T19:29:14Z
dc.date.available 2017-03-13T19:29:14Z
dc.date.issued 2014
dc.identifier.citation Biomed Res Int. 2014; 2014: 210424
dc.identifier.uri http://hdl.handle.net/11447/1018
dc.identifier.uri http://dx.doi.org/10.1155/2014/210424
dc.description Centro de Medicina Regenerativa
dc.description.abstract Prolactin (PRL) is a key player in the development of mammary cancer. We studied the effects of parity or hyperprolactinemia on mammary carcinogenesis in OFA hr/hr treated with 7,12-dimethylbenzanthracene. They were divided into three groups: nulliparous (Null), primiparous (PL, after pregnancy and lactation), and hyperprolactinemic rats (I, implanted in the arcuate nucleus with 17β-estradiol). The tumor incidence was similar in the three groups. However, a higher percentage of regressing tumors was evident in the PL group. Serum PRL, mammary development, and mammary β-casein content were higher in I rats compared to Null. The expression of hormone receptors was similar in the different groups. However, mammary tissue from PL rats bearing tumors had increased expression of PRL and estrogen alpha receptors compared to rats free of tumors. Our results suggest that serum PRL levels do not have relevance on the incidence of tumors, probably because the low levels of PRL in OFA rats are not further decreased by PL like in other strains. However, supraphysiological levels of PRL affect carcinogenesis. PL induces regression of the tumors due to the differentiation produced on the mammary cells. Alterations in the expression of hormonal receptors may be involved in progression and regression of tumors.
dc.format.extent 11
dc.language.iso en_US
dc.publisher Hindawi Publishing Corporation
dc.subject 9,10-Dimethyl-1,2-benzanthracene/toxicity
dc.subject Animals
dc.subject Carcinogens/toxicity
dc.subject Mammary Glands, Animal/pathology
dc.subject Prolactin/blood
dc.subject Rats
dc.title Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats
dc.type Artículo


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