Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats

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dc.contributor.authorSasso, Corina
dc.contributor.authorSantiano, Flavia
dc.contributor.authorLópez-Fontana, Constanza
dc.contributor.authorPistone-Creydt, Virginia
dc.contributor.authorEzquer, Marcelo
dc.contributor.authorHapon, María
dc.contributor.authorJahn, Graciela
dc.contributor.authorCarón, Rubén
dc.date.accessioned2017-03-13T19:29:14Z
dc.date.available2017-03-13T19:29:14Z
dc.date.issued2014
dc.descriptionCentro de Medicina Regenerativa
dc.description.abstractProlactin (PRL) is a key player in the development of mammary cancer. We studied the effects of parity or hyperprolactinemia on mammary carcinogenesis in OFA hr/hr treated with 7,12-dimethylbenzanthracene. They were divided into three groups: nulliparous (Null), primiparous (PL, after pregnancy and lactation), and hyperprolactinemic rats (I, implanted in the arcuate nucleus with 17β-estradiol). The tumor incidence was similar in the three groups. However, a higher percentage of regressing tumors was evident in the PL group. Serum PRL, mammary development, and mammary β-casein content were higher in I rats compared to Null. The expression of hormone receptors was similar in the different groups. However, mammary tissue from PL rats bearing tumors had increased expression of PRL and estrogen alpha receptors compared to rats free of tumors. Our results suggest that serum PRL levels do not have relevance on the incidence of tumors, probably because the low levels of PRL in OFA rats are not further decreased by PL like in other strains. However, supraphysiological levels of PRL affect carcinogenesis. PL induces regression of the tumors due to the differentiation produced on the mammary cells. Alterations in the expression of hormonal receptors may be involved in progression and regression of tumors.
dc.format.extent11
dc.identifier.citationBiomed Res Int. 2014; 2014: 210424
dc.identifier.urihttp://hdl.handle.net/11447/1018
dc.identifier.urihttp://dx.doi.org/10.1155/2014/210424
dc.language.isoen_US
dc.publisherHindawi Publishing Corporation
dc.subject9,10-Dimethyl-1,2-benzanthracene/toxicity
dc.subjectAnimals
dc.subjectCarcinogens/toxicity
dc.subjectMammary Glands, Animal/pathology
dc.subjectProlactin/blood
dc.subjectRats
dc.titleEffects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats
dc.typeArtículo

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