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White matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis

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dc.contributor.authorFigueroa-Vargas, Alejandra
dc.contributor.authorNavarrete-Caro, Sebastián
dc.contributor.authorCárcamo, Claudia
dc.contributor.authorCiampi, Ethel
dc.contributor.authorVásquez-Torres, Macarena
dc.contributor.authorSoler, Bernardita
dc.contributor.authorMontalba, Cristian
dc.contributor.authorIriarte-Carter, Matías
dc.contributor.authorMartínez-Molina, María Paz
dc.contributor.authorCarvajal-Paredes, Patricio
dc.contributor.authorAyala-Ochoa, Mariana
dc.contributor.authorMárquez-Rodríguez, Víctor
dc.contributor.authorFigueroa-Taiba, Paulo
dc.contributor.authorDíaz-Díaz, Marcela
dc.contributor.authorHerrero, Joaquín
dc.contributor.authorHenríquez-Ch., Rodrigo
dc.contributor.authorStecher, Ximena
dc.contributor.authorManterola, Carla
dc.contributor.authorZamorano, Francisco
dc.contributor.authorGuevara, Pamela
dc.contributor.authorAboitiz, Francisco
dc.contributor.authorBilleke, Pablo
dc.date.accessioned2026-07-17T15:19:16Z
dc.date.available2026-07-17T15:19:16Z
dc.date.issued2025
dc.description.abstractMultiple sclerosis (MS) is a prevalent neurological disorder marked by inflammation and demyelination, with fatigue being one of the most reported and debilitating symptoms. While fatigue occurs across various neurological conditions and even in healthy individuals, the specific mechanisms contributing to fatigue in each context remain unclear. In this study, we conducted a cross-sectional analysis involving 32 people with relapsing MS (PwRMS) and 29 healthy controls who reported fatigue. Participants underwent MRI scans, including T1-weighted and diffusion-weighted imaging. Additionally, the Modified Fatigue Impact Scale was utilized. We employed Bayesian LASSO and Spike-and-Slab LASSO regression models to investigate the hypothesis that fatigue correlates differently with brain structures in PwRMS. Our findings revealed brain regions associated with general and cognitive fatigue. In particular, reduced white matter volume and compromised microstructural integrity in specific areas—such as the cingulate gyrus, inferior frontal gyrus, and the banks of the superior temporal sulcus—showed significant associations with fatigue scores in PwRMS. These results suggest that alterations in specific brain regions may play a critical role in the clinical manifestation of fatigue in MS. Understanding these insights could help differentiate general mechanisms of fatigue from those affecting people with relapsing MS, which may guide future therapeutic strategies.
dc.description.versionVersión publicada
dc.format.extent16 p.
dc.identifier.citationSci Rep 15, 16417 (2025).
dc.identifier.doihttps://doi.org/10.1038/s41598-025-01465-6
dc.identifier.urihttps://hdl.handle.net/11447/10846
dc.language.isoen
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectPeople with relapsing multiple sclerosis (PwRMS)
dc.subjectFatigue
dc.subjectInferior frontal gyrus (IFG)
dc.subjectFrontal pole
dc.subjectMagnetic resonance imaging (MRI)
dc.subjectDiffusion tensor imaging (DTI)
dc.titleWhite matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceScience Report
dspace.entity.typePublication

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