Publication:
Documentary Analysis of Hypericum perforatum (St. John’s Wort) and Its Effect on Depressive Disorders

Simple item page
dc.contributor.authorOtero, María Carolina
dc.contributor.authorCeric Garrido, Francisco
dc.contributor.authorMiranda-Rojas, Sebastián
dc.contributor.authorEscobar, María José
dc.contributor.authorSaracini, Chiara
dc.contributor.authorAtala, Cristian
dc.contributor.authorCarreño, Carolina
dc.contributor.authorEscares, Rachelly
dc.contributor.authorRamírez-Barrantes, Ricardo
dc.contributor.authorGordillo-Fuenzalida, Felipe
dc.date.accessioned2025-08-20T17:35:32Z
dc.date.available2025-08-20T17:35:32Z
dc.date.issued2024
dc.description.abstractHypericum perforatum, also known as St. John’s Wort, pericon, or yellow grass, is known for its antidepressant potential. It could represent a natural alternative to current pharmacological antidepressant treatments, which have a high incidence of side effects in patients and therefore lead to early dropouts. Through a bibliographic revision of clinical trials and information collected from scientific articles during the first period of 2020, we aimed to evaluate whether its administration could be beneficial in the treatment of mild-to-moderate depression, with fewer side effects compared to synthetic drugs. Among the main components, hypericin and hyperforin have been related to the observed antidepressant activity; therefore, their possible mechanism of action was reviewed and highlighted. Furthermore, patients receiving Hypericum extracts were less likely to withdraw from studies because of adverse effects compared to those receiving older standard antidepressants. This review aims to provide suggestions for an alternative treatment of mild-to-moderate depression disorder under the supervision of a medical doctor, since, although it appears to be a potentially efficient treatment with a low presence of adverse effects in comparison to synthetic antidepressants, it might also interact with other medications and lead to therapeutic failures if misused for self-medication.
dc.description.versionVersión publicada
dc.format.extent18 p.
dc.identifier.citationOtero, M. C., Ceric, F., Miranda-Rojas, S., Carreño, C., Escares, R., Escobar, M. J., Saracini, C., Atala, C., Ramírez-Barrantes, R., & Gordillo-Fuenzalida, F. (2024). Documentary Analysis of Hypericum perforatum (St. John’s Wort) and Its Effect on Depressive Disorders. Pharmaceuticals, 17(12), 1625. https://doi.org/10.3390/ph17121625
dc.identifier.doihttps://doi.org/10.3390/ph17121625
dc.identifier.urihttps://hdl.handle.net/11447/10194
dc.language.isoen
dc.subjectMedicinal plants
dc.subjectNaphthodianthrones
dc.subjectPhloroglucinols
dc.subjectAntidepressants
dc.titleDocumentary Analysis of Hypericum perforatum (St. John’s Wort) and Its Effect on Depressive Disorders
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourcePharmaceuticals
dspace.entity.typePublication
relation.isAuthorOfPublication17422351-3474-4296-b25b-bf44debb21b6
relation.isAuthorOfPublication.latestForDiscovery17422351-3474-4296-b25b-bf44debb21b6

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
pharmaceuticals-17-01625-v2.pdf
Size:
1.36 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
347 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Psicología

Implementado por OpenGeek Services