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Sample Ascertainment and recruitment sources in the Accelerating Medicines Partnership Schizophrenia Program

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dc.contributor.authorAddington, Jean
dc.contributor.authorShalev, Amy
dc.contributor.authorLiu, Lu
dc.contributor.authorJahraus, Cari
dc.contributor.authorChu, Monica
dc.contributor.authorFarina, Emily
dc.contributor.authorFusar Poli, Paolo
dc.contributor.authorMarcy, Patricia J.
dc.contributor.authorNunez, Angela R.
dc.contributor.authorCalkins, Monica E.
dc.contributor.authorAlameda, Luis
dc.contributor.authorArango, Celso
dc.contributor.authorBorders, Owen
dc.contributor.authorBouix, Sylvain
dc.contributor.authorBreitborde, Nicholas J. K.
dc.contributor.authorBroome, Matthew R.
dc.contributor.authorCadenhead, Kristin S.
dc.contributor.authorCarrion, Ricardo E.
dc.contributor.authorCastillo-Passi, Rolando I.
dc.contributor.authorChen, Eric Yu Hai
dc.contributor.authorChoi, Jimmy
dc.contributor.authorColeman, Michael J.
dc.contributor.authorConus, Philippe
dc.contributor.authorCorcoran, Cheryl M.
dc.contributor.authorDiaz-Caneja, Covadonga M.
dc.contributor.authorEllman, Lauren M.
dc.contributor.authorGaspar, Pablo A.
dc.contributor.authorGerber, Carla
dc.contributor.authorGlenthøj, Louise Birkedal
dc.contributor.authorHorton, Leslie E.
dc.contributor.authorHui, Christy Lai Ming
dc.contributor.authorKambeitz, Joseph
dc.contributor.authorKambeitz-Ilankovic, Lana
dc.contributor.authorKapur, Tina
dc.contributor.authorKelly, Sinead
dc.contributor.authorKerr, Melissa J.
dc.contributor.authorKeshavan, Matcheri S.
dc.contributor.authorKim, Minah
dc.contributor.authorKim, Sung-Wan
dc.contributor.authorKoutsouleris, Nikolaos
dc.date.accessioned2026-07-23T13:05:30Z
dc.date.available2026-07-23T13:05:30Z
dc.date.issued2025
dc.descriptionJun Soo Kwon; Kerstin Langbein; Kathryn E .Lewandowski; Daniel Mamah; Daniel H. Mathalon; Vijay A. Mittal; Catalina Mourgues; Merete Nordentoft; Ofer Pasternak; Godfrey D. Pearlson; Nora Penzel; Jesus Perez; Diana O.Perkins; Albert R. Powers III; Jack Rogers; Fred W. Sabb; Jason Schiffman; Johanna Seitz-Holland; Jai L. Shah; Steven M. Silverstein; Stefan Smesny; William S. Stone; Gregory P. Strauss; Judy L. Thompson; Rachel Upthegrove; Swapna Verma; Jijun Wang; Daniel H. Wolf; Alison R. Yung; Tianhong Zhang; Lauren Addamo; Kate Buccilli; Sophie Todd; Dominic Dwyer; Carrie E. Bearden; John M. Kane; Patrick D. McGorry; Rene S. Kahn; Martha E. Shenton; Scott W. Woods; Accelerating Medicines Partnership® Schizophrenia; Barnaby Nelson
dc.description.abstractBackground. This paper presents the recruitment sources of clinical high-risk (CHR) and community controls (CC) from the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) program, which aims to study various clinical variables and biomarkers in 2040 CHR and 652 CC participants. Methods. A total of 1640 CHR and 514 CC had recruitment source data. The Positive Symptoms and Diagnostic Criteria for the Comprehensive Assessment of At-Risk Mental States Harmonized with the SIPS was utilized to assess CHR criteria and severity of attenuated psychotic symptoms (APSs), and the Global Functioning: Social Scale was used for social functioning. Participants were recruited through various methods, including referrals from healthcare providers, schools, and community agencies, and self-referrals via outreach efforts and advertising. Results. Participants were recruited from 13 different sources, with self-referral being the most common for both CHR and CC. Other notable sources included child and youth services and psychiatric hospitals and departments. Regional differences in recruitment patterns were observed across continents. Differences in age, APS, and social functioning for CHR participants were examined in the top 5 recruitment sources. Overall, self-referred individuals were typically older, with less severe APS and higher levels of functioning, whereas those from adult community mental health services had poorer functioning and more severe APS. The remaining recruitment groups fell between these 2 extremes. Conclusion. This paper highlights the diverse recruitment sources for the AMP SCZ program. Self-referral was a significant source, particularly in North America, reflecting changing help-seeking behaviors influenced by the internet and social media. The findings underscore the importance of understanding recruitment sources to optimize future CHR research.
dc.description.versionVersión publicada
dc.format.extent13 p.
dc.identifier.citationAddington, J., Shalev, A., Liu, L., Jahraus, C., Chu, M., Farina, E., Fusar Poli, P., Marcy, P. J., Nunez, A. R., Calkins, M. E., Alameda, L., Arango, C., Borders, O., Bouix, S., Breitborde, N. J. K., Broome, M. R., Cadenhead, K. S., Carrion, R. E., Castillo-Passi, R. I., … Accelerating Medicines Partnership® Schizophrenia Nelson Barnaby. (2025). Sample ascertainment and recruitment sources in the Accelerating Medicines Partnership Schizophrenia Program. Schizophrenia Bulletin Open, 6(1), sgaf013. https://doi.org/10.1093/schizbullopen/sgaf013
dc.identifier.doihttps://doi.org/10.1093/schizbullopen/sgaf013
dc.identifier.urihttps://hdl.handle.net/11447/10900
dc.language.isoen
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectClinical high risk
dc.subjectCommunity controls
dc.subjectPsychosis
dc.subjectAscertainment
dc.subjectRecruitment
dc.subjectAMP SCZ
dc.titleSample Ascertainment and recruitment sources in the Accelerating Medicines Partnership Schizophrenia Program
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceSchizophrenia Bulletin Open
dspace.entity.typePublication

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