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Age and primary vaccination schedule impact humoral and cellular immunity with an inactivated SARS-CoV-2 vaccine

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dc.contributor.authorMartínez, Yohana
dc.contributor.authorRodríguez, Linmar
dc.contributor.authorMéndez, Constanza
dc.contributor.authorRíos, Mariana
dc.contributor.authorRivera, Daniela
dc.contributor.authorMoreno, Daniela
dc.contributor.authorReyes, Humberto
dc.contributor.authorPereira, Patricia
dc.contributor.authorOrellana, Claudia
dc.contributor.authorCabrera, Alex
dc.contributor.authorSchultz, Bárbara
dc.contributor.authorDuarte, Luisa
dc.contributor.authorGálvez, Nicolás
dc.contributor.authorMelo, Felipe
dc.contributor.authorSoto, Jorge
dc.contributor.authorIturriaga, Carolina
dc.contributor.authorUrzúa, Marcela
dc.contributor.authorNavarrete, Marıía
dc.contributor.authorRojas, Álvaro
dc.contributor.authorFasce, Rodrigo
dc.contributor.authorFernández, Jorge
dc.contributor.authorMora, Judith
dc.contributor.authorRamíez, Eugenio
dc.contributor.authorWeiskopf, Daniela
dc.contributor.authorGrifoni, Alba
dc.contributor.authorSette, Alessandro
dc.contributor.authorZeng, Gang
dc.contributor.authorMeng, Weining
dc.contributor.authorCoronaVac03CL Study Group
dc.contributor.authorAlvarez, María
dc.contributor.authorGonzález, Jose
dc.contributor.authorDomínguez, M. Angélica
dc.contributor.authorGonzález, Pablo
dc.contributor.authorAbarca, Katia
dc.contributor.authorPeñaloza, Hernán
dc.contributor.authorBueno, Susan
dc.contributor.authorKalergis, Alexis
dc.date.accessioned2026-09-07T15:00:12Z
dc.date.available2026-09-07T15:00:12Z
dc.date.issued2025
dc.description.abstractDespite widespread COVID-19 vaccination, questions remain about vaccine safety and immunogenicity in vulnerable populations, such as older adults. We evaluated the safety and immunogenicity of four doses of CoronaVac in adults above and below 60 who received the first two doses in two different schedules (0-14 and 0-28 days apart). While CoronaVac demonstrated excellent safety across age groups, older adults showed reduced reactogenicity. In the 0-28 schedule, both age groups exhibited similar frequencies of SARS-CoV-2-specific CD4+ and CD8+ T cells, though memory T cell distribution patterns differed. Notably, adults over 60 showed diminished virus-neutralizing antibody responses compared to younger participants. The 0-14 schedule produced equivalent cellular and neutralizing antibody responses between age groups, albeit at lower levels than the 0-28 schedule. Our data indicate that primary vaccination schedules can influence the humoral immune responses and memory T cell distribution between age groups.
dc.description.versionVersión Publicada
dc.identifier.citationMartínez-Balboa Y, Rodríguez-Guilarte L, Méndez C, Ríos M, Rivera DB, Moreno-Tapia D, Reyes HA, Pereira-Sánchez P, Orellana C, Cabrera A, Schultz BM, Duarte LF, Gálvez NMS, Melo-González F, Soto JA, Iturriaga C, Urzúa M, Navarrete MS, Rojas Á, Fasce RA, Fernández J, Mora J, Ramírez E, Weiskopf D, Grifoni A, Sette A, Zeng G, Meng W; CoronaVac03CL Study Group; Alvarez-Figueroa MJ, González-Aramundiz JV, Domínguez MA, González PA, Abarca K, Peñaloza HF, Bueno SM, Kalergis AM. Age and primary vaccination schedule impact humoral and cellular immunity with an inactivated SARS-CoV-2 vaccine. iScience. 2025 Jul 21;28(8):113167. doi: 10.1016/j.isci.2025.113167
dc.identifier.doihttps://doi.org/10.1016/j.isci.2025.11316
dc.identifier.urihttps://hdl.handle.net/11447/11068
dc.language.isoen
dc.subjectImmune response
dc.titleAge and primary vaccination schedule impact humoral and cellular immunity with an inactivated SARS-CoV-2 vaccine
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceiScience
dspace.entity.typePublication

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