Age and primary vaccination schedule impact humoral and cellular immunity with an inactivated SARS-CoV-2 vaccine

Martínez, Yohana; Rodríguez, Linmar; Méndez, Constanza; Ríos, Mariana; Rivera, Daniela; Moreno, Daniela; Reyes, Humberto; Pereira, Patricia; Orellana, Claudia; Cabrera, Alex; Schultz, Bárbara; Duarte, Luisa; Gálvez, Nicolás; Melo, Felipe; Soto, Jorge; Iturriaga, Carolina; Urzúa, Marcela; Navarrete, Marıía; Rojas, Álvaro; Fasce, Rodrigo; Fernández, Jorge; Mora, Judith; Ramíez, Eugenio; Weiskopf, Daniela; Grifoni, Alba; Sette, Alessandro; Zeng, Gang; Meng, Weining; CoronaVac03CL Study Group; Alvarez, María; González, Jose; Domínguez, M. Angélica; González, Pablo; Abarca, Katia; Peñaloza, Hernán; Bueno, Susan; Kalergis, Alexis

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Age and primary vaccination schedule impact humoral and cellular immunity with an inactivated SARS-CoV-2 vaccine

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Article Age and primary vaccination schedule impact humoral and cellular immunity with an inactivated SARS-CoV-2 vaccine.pdf (7.08 MB)

Date

2025

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Article

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Artículos Medicina y Ciencias de la Salud

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https://doi.org/10.1016/j.isci.2025.11316

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https://hdl.handle.net/11447/11068

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Abstract

Despite widespread COVID-19 vaccination, questions remain about vaccine safety and immunogenicity in vulnerable populations, such as older adults. We evaluated the safety and immunogenicity of four do...

Citation

Martínez-Balboa Y, Rodríguez-Guilarte L, Méndez C, Ríos M, Rivera DB, Moreno-Tapia D, Reyes HA, Pereira-Sánchez P, Orellana C, Cabrera A, Schultz BM, Duarte LF, Gálvez NMS, Melo-González F, Soto JA, Iturriaga C, Urzúa M, Navarrete MS, Rojas Á, Fasce RA, Fernández J, Mora J, Ramírez E, Weiskopf D, Grifoni A, Sette A, Zeng G, Meng W; CoronaVac03CL Study Group; Alvarez-Figueroa MJ, González-Aramundiz JV, Domínguez MA, González PA, Abarca K, Peñaloza HF, Bueno SM, Kalergis AM. Age and primary vaccination schedule impact humoral and cellular immunity with an inactivated SARS-CoV-2 vaccine. iScience. 2025 Jul 21;28(8):113167. doi: 10.1016/j.isci.2025.113167

Keywords

Immune response

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