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Network anatomy in logopenic variant of primary progressive aphasia

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dc.contributor.authorMandelli, Maria Luisa
dc.contributor.authorLorca-Puls, Diego L.
dc.contributor.authorLukic, Sladjana
dc.contributor.authorMontembeault, Maxime
dc.contributor.authorGajardo-Vidal, Andrea
dc.contributor.authorLicata, Abigail
dc.contributor.authorScheffler, Aaron
dc.contributor.authorBattistella, Giovanni
dc.contributor.authorGrasso, Stephanie M.
dc.contributor.authorBogley, Rian
dc.contributor.authorRatnasiri, Buddhika M.
dc.contributor.authorLa Joie, Renaud
dc.contributor.authorMundada, Nidhi S.
dc.contributor.authorEuropa, Eduardo
dc.contributor.authorRabinovici, Gil
dc.contributor.authorMiller, Bruce L.
dc.contributor.authorLeon, Jessica De
dc.contributor.authorHenry, Maya L.
dc.contributor.authorMiller, Zachary
dc.contributor.authorGorno-Tempini, Maria Luisa
dc.date.accessioned2024-05-17T14:13:50Z
dc.date.available2024-05-17T14:13:50Z
dc.date.issued2023
dc.description.abstractThe logopenic variant of primary progressive aphasia (lvPPA) is a neurodegenerative syndrome characterized linguistically by gradual loss of repetition and naming skills resulting from left posterior temporal and inferior parietal atrophy. Here, we sought to identify which specific cortical loci are initially targeted by the disease (epicenters) and investigate whether atrophy spreads through predetermined networks. First, we used cross-sectional structural MRI data from individuals with lvPPA to define putative disease epicenters using a surface-based approach paired with an anatomically fine-grained parcellation of the cortical surface (i.e., HCP-MMP1.0 atlas). Second, we combined cross-sectional functional MRI data from healthy controls and longitudinal structural MRI data from individuals with lvPPA to derive the epicenter-seeded resting-state networks most relevant to lvPPA symptomatology and ascertain whether functional connectivity in these networks predicts longitudinal atrophy spread in lvPPA. Our results show that two partially distinct brain networks anchored to the left anterior angular and posterior superior temporal gyri epicenters were preferentially associated with sentence repetition and naming skills in lvPPA. Critically, the strength of connectivity within these two networks in the neurologically-intact brain significantly predicted longitudinal atrophy progression in lvPPA. Taken together, our findings indicate that atrophy progression in lvPPA, starting from inferior parietal and temporoparietal junction regions, predominantly follows at least two partially nonoverlapping pathways, which may influence the heterogeneity in clinical presentation and prognosis.
dc.description.versionVersión publicada
dc.format.extent17 p.
dc.identifier.citationHum Brain Mapp. 2023 Aug 1;44(11):4390-4406.
dc.identifier.doihttps://doi.org/10.1002/hbm.26388.
dc.identifier.urihttps://hdl.handle.net/11447/8823
dc.language.isoen
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectAlzheimer's disease
dc.subjectCortical atrophy
dc.subjectIntrinsic connectivity networks
dc.subjectLogopenic variant
dc.subjectLongitudinal study
dc.subjectPrimary progressive aphasia
dc.titleNetwork anatomy in logopenic variant of primary progressive aphasia
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceHuman Brain Mapping
dspace.entity.typePublication
relation.isAuthorOfPublicationb626aa2c-f91d-453f-abd3-e99e74388cef
relation.isAuthorOfPublication.latestForDiscoveryb626aa2c-f91d-453f-abd3-e99e74388cef

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