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β-Cyclodextrin nanosponges inclusion compounds associated with silver nanoparticles to increase the antimicrobial activity of quercetin

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dc.contributor.authorSalazar Sandoval, Sebastián
dc.contributor.authorBruna, Tamara
dc.contributor.authorMaldonado-Bravo, Francisca
dc.contributor.authorBolaños, Karen
dc.contributor.authorAdasme-Reyes, Sofía
dc.contributor.authorRiveros, Ana
dc.contributor.authorCaro, Nelson
dc.contributor.authorYutronic, Nicolás
dc.contributor.authorSilva, Nataly
dc.contributor.authorKogan, Marcelo J.
dc.contributor.authorJara, Paul
dc.date.accessioned2024-05-16T13:21:15Z
dc.date.available2024-05-16T13:21:15Z
dc.date.issued2023
dc.description.abstractThis work aimed to synthesize and characterize a nanocarrier that consisted of a ternary system, namely β-cyclodextrin-based nanosponge (NS) inclusion compounds (ICs) associated with silver nanoparticles (AgNPs) to increase the antimicrobial activity of quercetin (QRC). The nanosystem was developed to overcome the therapeutical limitations of QRC. The host–guest interaction between NSs and QRC was confirmed by field emission scanning electron microscopy (FE–SEM), X-ray powder diffraction (XRPD), thermogravimetric analysis (TGA), and proton nuclear magnetic resonance (1H–NMR). Moreover, the association of AgNPs with the NS–QRC was characterized using FE–SEM, energy-dispersive spectroscopy (EDS), transmission electron microscopy (TEM), dynamic light scattering (DLS), ζ-potential, and UV–Vis. Finally, the antimicrobial activity of the novel formulations was tested, which depicted that the complexation of QRC inside the supramolecular interstices of NSs increases the inhibitory effects against Escherichia coli ATCC25922, as compared to that observed in the free QRC. In addition, at the same concentrations used to generate an antibacterial effect, the NS–QRC system with AgNPs does not affect the metabolic activity of GES–1 cells. Therefore, these results suggest that the use of NSs associated with AgNPs resulted in an efficient strategy to improve the physicochemical features of QRC.
dc.identifier.citationMaterials (Basel). 2023 May 5;16(9):3538.
dc.identifier.doihttps://doi.org/10.3390/ma16093538
dc.identifier.urihttps://hdl.handle.net/11447/8782
dc.language.isoen
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectβ-cyclodextrin-based nanosponges
dc.subjectAntimicrobials
dc.subjectQuercetin
dc.subjectSilver nanoparticles
dc.subjectPlasmon surface resonance
dc.subjectAntimicrobial activity
dc.titleβ-Cyclodextrin nanosponges inclusion compounds associated with silver nanoparticles to increase the antimicrobial activity of quercetin
dc.typeArticle
dcterms.accessRightsAcceso abierto
dspace.entity.typePublication
relation.isAuthorOfPublication603f2ee7-db8e-41b0-8451-b1ca8a5328df
relation.isAuthorOfPublication.latestForDiscovery603f2ee7-db8e-41b0-8451-b1ca8a5328df

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