Publication:
Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations

Simple item page
dc.contributor.authorKausel, Leonie
dc.contributor.authorFigueroa-Vargas, Alejandra
dc.contributor.authorZamorano, Francisco
dc.contributor.authorStecher, Ximena
dc.contributor.authorAspé-Sánchez, Mauricio
dc.contributor.authorCarvajal-Paredes, Patricio
dc.contributor.authorMárquez-Rodríguez, Víctor
dc.contributor.authorMartínez-Molina, María Paz
dc.contributor.authorRomán, Claudio
dc.contributor.authorSoto-Fernández, Patricio
dc.contributor.authorValdebenito-Oyarzo, Gabriela
dc.contributor.authorManterola, Carla
dc.contributor.authorUribe-San-Martín, Reinaldo
dc.contributor.authorSilva, Claudio
dc.contributor.authorHenríquez-Ch, Rodrigo
dc.contributor.authorAboitiz, Francisco
dc.contributor.authorPolania, Rafael
dc.contributor.authorGuevara, Pamela
dc.contributor.authorMuñoz-Venturelli, Paula
dc.contributor.authorSoto-Icaza, Patricia
dc.contributor.authorBilleke, Pablo
dc.date.accessioned2024-09-10T21:36:54Z
dc.date.available2024-09-10T21:36:54Z
dc.date.issued2024
dc.description.abstractPatients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms and risk factors underlying these alterations remain elusive. Given the significant global incidence of COVID-19, identifying factors that can distinguish individuals at risk of developing brain alterations is crucial for prioritizing follow-up care. Here, we report findings from a sample of patients consisting of 73 adults with a mild to moderate SARS-CoV-2 infection without signs of respiratory failure and 27 with infections attributed to other agents and no history of COVID-19. The participants underwent cognitive screening, a decision-making task, and MRI evaluations. We assessed for the presence of anosmia and the requirement for hospitalization. Groups did not differ in age or cognitive performance. Patients who presented with anosmia exhibited more impulsive alternative changes after a shift in probabilities (r =  − 0.26, p = 0.001), while patients who required hospitalization showed more perseverative choices (r = 0.25, p = 0.003). Anosmia correlated with brain measures, including decreased functional activity during the decision-making task, thinning of cortical thickness in parietal regions, and loss of white matter integrity. Hence, anosmia could be a factor to be considered when identifying at-risk populations for follow-up
dc.format.extent14 p.
dc.identifier.citationKausel, L., Figueroa-Vargas, A., Zamorano, F. et al. Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations. Sci Rep 14, 19049 (2024). https://doi.org/10.1038/s41598-024-69772-y
dc.identifier.doihttps://doi.org/10.1038/s41598-024-69772-y
dc.identifier.urihttps://hdl.handle.net/11447/9296
dc.language.isoen
dc.subjectSARS-CoV-2
dc.subjectLong-term COVID-19
dc.subjectDecision-making
dc.subjectMRI
dc.subjectDTI
dc.subjectCognitive impairments
dc.titlePatients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceScientific Reports
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
s41598-024-69772-y (1).pdf
Size:
1.72 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
347 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Gobierno

Implementado por OpenGeek Services