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The parietal cortex has a causal role in ambiguity computations in humans

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dc.contributor.authorValdebenito-Oyarzo, Gabriela
dc.contributor.authorMartínez-Molina, María Paz
dc.contributor.authorSoto-Icaza, Patricia
dc.contributor.authorZamorano, Francisco
dc.contributor.authorFigueroa-Vargas, Alejandra
dc.contributor.authorLarraín-Valenzuela, Josefina
dc.contributor.authorStecher, Ximena
dc.contributor.authorSalinas, César
dc.contributor.authorBastin, Julien
dc.contributor.authorValero-Cabré, Antoni
dc.contributor.authorPolania, Rafael
dc.contributor.authorBilleke, Pablo
dc.date.accessioned2025-01-30T19:51:12Z
dc.date.available2025-01-30T19:51:12Z
dc.date.issued2024
dc.description.abstractHumans often face the challenge of making decisions between ambiguous options. The level of ambiguity in decision-making has been linked to activity in the parietal cortex, but its exact computational role remains elusive. To test the hypothesis that the parietal cortex plays a causal role in computing ambiguous probabilities, we conducted consecutive fMRI and TMS-EEG studies. We found that participants assigned unknown probabilities to objective probabilities, elevating the uncertainty of their decisions. Parietal cortex activity correlated with the objective degree of ambiguity and with a process that underestimates the uncertainty during decision-making. Conversely, the midcingulate cortex (MCC) encodes prediction errors and increases its connectivity with the parietal cortex during outcome processing. Disruption of the parietal activity increased the uncertainty evaluation of the options, decreasing cingulate cortex oscillations during outcome evaluation and lateral frontal oscillations related to value ambiguous probability. These results provide evidence for a causal role of the parietal cortex in computing uncertainty during ambiguous decisions made by humans.
dc.description.versionVersión publicada
dc.format.extent30 p.
dc.identifier.citationValdebenito-Oyarzo G, Martínez-Molina MP, Soto-Icaza P, Zamorano F, Figueroa-Vargas A, Larraín-Valenzuela J, et al. (2024) The parietal cortex has a causal role in ambiguity computations in humans. PLoS Biol 22(1): e3002452. https://doi.org/10.1371/journal.pbio.3002452
dc.identifier.doihttps://doi.org/10.1371/journal.pbio.3002452
dc.identifier.urihttps://hdl.handle.net/11447/9758
dc.language.isoen
dc.relation.project1211227,1181295,11230607,PAI77190047,EQM150076 This work was supported by Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT, 1211227, 1181295 to PB, and 11230607 to PSI), Agencia Nacional de Investigacion y Desarrollo (ANID, PAI77190047 to PSI, EQM150076 to PB, C12S03 to JB and PB). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.
dc.subjectParietal cortex
dc.subjectGeneral Neuroscience
dc.titleThe parietal cortex has a causal role in ambiguity computations in humans
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourcePLoS Biology
dspace.entity.typePublication
relation.isAuthorOfPublication918d576e-0c4f-4436-b54f-58e78c61e23a
relation.isAuthorOfPublication.latestForDiscovery918d576e-0c4f-4436-b54f-58e78c61e23a

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