Publication: Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
| dc.contributor.author | KLEIN, ANDRES | |
| dc.contributor.author | Outeiro, Tiago Fleming | |
| dc.date.accessioned | 2023-10-25T20:37:20Z | |
| dc.date.available | 2023-10-25T20:37:20Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly described role of GCase in the mitochondria will inform new Parkinson’s and Gaucher’s disease therapeutics. | |
| dc.description.version | Versión publicada | |
| dc.format.extent | 3 p. | |
| dc.identifier.citation | Klein, A.D., Outeiro, T.F. Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria. Nat Commun 14, 6383 (2023). https://doi.org/10.1038/s41467-023-42107-7 | |
| dc.identifier.doi | https://doi.org/10.1038/s41467-023-42107-7 | |
| dc.identifier.uri | https://repositorio.udd.cl/handle/11447/8022 | |
| dc.language.iso | en | |
| dc.subject | Molecular medicine | |
| dc.subject | Organelles | |
| dc.subject | Parkinson's disease | |
| dc.title | Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria | |
| dc.type | Article | |
| dcterms.accessRights | Acceso abierto | |
| dcterms.source | Nature Communications | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | c1e7074e-9371-438f-ac60-64cc46fca1c5 | |
| relation.isAuthorOfPublication.latestForDiscovery | c1e7074e-9371-438f-ac60-64cc46fca1c5 |