Publication: Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
Date
2023
Authors
Outeiro, Tiago Fleming
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly described role of GCase in the mitochondria will inform new Parkinson’s and Gaucher’s disease therapeutics.
Description
Keywords
Molecular medicine, Organelles, Parkinson's disease
Citation
Klein, A.D., Outeiro, T.F. Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria. Nat Commun 14, 6383 (2023). https://doi.org/10.1038/s41467-023-42107-7