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Advances in lung cancer basic and translational research in 2025 - Overview and perspectives focusing on non-small cell lung cancer

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dc.contributor.authorMascaux, Celine
dc.contributor.authorSen, Triparna
dc.contributor.authorSanchez, Montse
dc.contributor.authorOrtiz, Sandra
dc.contributor.authorBossé, Yohan
dc.contributor.authorDammeijer, Floris
dc.contributor.authorCavic, Milena
dc.contributor.authorBarr, Martin
dc.contributor.authorArulananda, Surein
dc.contributor.authorArmisen, Ricardo
dc.contributor.authorBerge, Alice
dc.contributor.authorBianchi, Fabrizio
dc.contributor.authorCarbone, David
dc.contributor.authorCerciello, Ferdinando
dc.contributor.authorLockwood, William
dc.contributor.authorMitsudomi, Tetsuya
dc.contributor.authorOhara, Shuta
dc.contributor.authorPoliti, Katerina
dc.contributor.authorQin, Sida
dc.contributor.authorRoisman, Laila
dc.contributor.authorSamstein, Robert
dc.contributor.authorSkoulidis, Ferdinandos
dc.contributor.authorTan, Aaron
dc.contributor.authorThomas, Anish
dc.contributor.authorZhang, Jianjun
dc.contributor.authorWynes, Murry
dc.contributor.authorJohn, Thomas
dc.contributor.authorSound, Ming
dc.contributor.authorIASLC Basic and Translational Science Committee
dc.date.accessioned2025-06-24T22:21:26Z
dc.date.available2025-06-24T22:21:26Z
dc.date.issued2025
dc.description.abstractBasic and translational research in lung cancer is a rapidly evolving field with transformational impact in early detection, diagnosis, therapeutic development and personalization of care. Recent advances have greatly increased our understanding in the molecular genomics, proteomics, pathogenesis and cellular biology of this deadly malignancy. The International Association for the Study of Lung Cancer (IASLC) recently formed a Basic and Translational Science (BaTS) Committee to further enhance the scientific leadership of IASLC in thoracic cancer research. This review by members of the committee highlights the breadth of current research in NSCLC, with a focus on molecular risk factors and processes in tumorigenesis, heterogeneity, phenotypic plasticity, metabolic reprograming, immunobiology, the immune microenvironment and microbiome. This review also identifies future research areas that may lead to further improvement in survival outcomes and curative therapies especially for patients with advanced NSCLC.
dc.description.versionVersión Aceptada
dc.identifier.citationMascaux C, Sen T, Sanchez-Cespedes M, Ortiz-Cuaran S, Bossé Y, Dammeijer F, Cavic M, Barr MP, Arulananda S, Armisen R, Berger AH, Bianchi F, Carbone DP, Cerciello F, Lockwood WW, Mitsudomi T, Ohara S, Politi K, Qin S, Roisman LC, Samstein R, Skoulidis F, Tan AC, Thomas A, Zhang J, Wynes MW, John T, Tsao MS; IASLC Basic and Translational Science Committee. Advances in lung cancer basic and translational research in 2025 - Overview and perspectives focusing on non-small cell lung cancer. J Thorac Oncol. 2025 Jun 3:S1556-0864(25)00754-3. doi: 10.1016/j.jtho.2025.05.024
dc.identifier.doihttps://doi.org/10.1016/j.jtho.2025.05.024
dc.identifier.urihttps://hdl.handle.net/11447/10106
dc.language.isoen
dc.subjectNSCLC
dc.subjectTME
dc.subjectCancer plasticity
dc.subjectEarly lung cancer
dc.subjectGenomics
dc.subjectImmune microenvironment
dc.subjectStates of art
dc.subjectTranslational research
dc.subjectTumor heterogeneity
dc.titleAdvances in lung cancer basic and translational research in 2025 - Overview and perspectives focusing on non-small cell lung cancer
dc.typeArticle
dcterms.accessRightsEmbargo
dcterms.sourceJournal of Thoracic Oncology
dspace.entity.typePublication
relation.isAuthorOfPublicationf814e5ac-2623-4a1f-bc2b-5a1a260ee316
relation.isAuthorOfPublication.latestForDiscoveryf814e5ac-2623-4a1f-bc2b-5a1a260ee316

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