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Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome

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dc.contributor.authorRisal, Sanjiv
dc.contributor.authorLi, Congru
dc.contributor.authorLuo, Qing
dc.contributor.authorFornes, Romina
dc.contributor.authorLu, Haojiang
dc.contributor.authorEriksson, Gustaw
dc.contributor.authorManti, Maria
dc.contributor.authorOhlsson, Claes
dc.contributor.authorLindgren, Eva
dc.contributor.authorCrisosto, Nicólas
dc.contributor.authorMaliqueo, Manuel
dc.contributor.authorEchiburú, Barbara
dc.contributor.authorRecabarren, Sergio
dc.contributor.authorSir Petermann, Teresa
dc.contributor.authorBenrick, Anna
dc.contributor.authorBrusselaers, Nele
dc.contributor.authorQiao, Jie
dc.contributor.authorDeng, Qiaolin
dc.contributor.authorStener-Victorin, Elisabet
dc.date.accessioned2024-04-23T21:14:34Z
dc.date.available2024-04-23T21:14:34Z
dc.date.issued2023
dc.description.abstractThe transgenerational maternal effects of polycystic ovary syndrome (PCOS) in female progeny are being revealed. As there is evidence that a male equivalent of PCOS may exists, we ask whether sons born to mothers with PCOS (PCOS-sons) transmit reproductive and metabolic phenotypes to their male progeny. Here, in a register-based cohort and a clinical case-control study, we find that PCOS-sons are more often obese and dyslipidemic. Our prenatal androgenized PCOS-like mouse model with or without diet-induced obesity confirmed that reproductive and metabolic dysfunctions in first-generation (F1) male offspring are passed down to F3. Sequencing of F1-F3 sperm reveals distinct differentially expressed (DE) small non-coding RNAs (sncRNAs) across generations in each lineage. Notably, common targets between transgenerational DEsncRNAs in mouse sperm and in PCOS-sons serum indicate similar effects of maternal hyperandrogenism, strengthening the translational relevance and highlighting a previously underappreciated risk of transmission of reproductive and metabolic dysfunction via the male germline.
dc.description.versionPublicada
dc.identifier.citationRisal S, Li C, Luo Q, Fornes R, Lu H, Eriksson G, Manti M, Ohlsson C, Lindgren E, Crisosto N, Maliqueo M, Echiburú B, Recabarren S, Petermann TS, Benrick A, Brusselaers N, Qiao J, Deng Q, Stener-Victorin E. Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome. Cell Rep Med. 2023 May 16;4(5):101035. doi: 10.1016/j.xcrm.2023.101035
dc.identifier.doihttps://doi.org/10.1016/j.xcrm.2023.101035
dc.identifier.urihttps://hdl.handle.net/11447/8673
dc.language.isoen
dc.subjectAdipose tissue
dc.subjectMale offspring
dc.subjectMale offspring to male germline
dc.subjectmaternal hyperandrogenism
dc.subjectMaternal obesity
dc.subjectPolycystic ovary syndrome
dc.subjectSmall non-coding RNAs
dc.subjectSperm
dc.titleTransgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceCell reports. Medicine
dspace.entity.typePublication

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