Publication: Molecular dynamics simulations reveal molecular mechanisms for the gain and loss of function effects of four SCN2A variants
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Authors
Bhattarai, Nisha
Montanucci, Ludovica
Brünger, Tobias
Martin, William
Smith, Iris
Eng, Charis
Cheng, Feixiong
Helbig, Ingo
Müller, Rikke
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Abstract
SCN2A gene disorders cover a wide range of medical conditions, from epileptic encephalopathies to neurodevelopmental disorders. The variants of these disorders, studied through electrophysiology, show...
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Bhattarai, N., Montanucci, L., Brünger, T., Pérez-Palma, E., Martin, W., Smith, I. N., Eng, C., Cheng, F., Helbig, I., Møller, R. S., Brunklaus, A., Schorge, S., & Lal, D. (2024). Molecular dynamics simulations reveal molecular mechanisms for the gain and loss of function effects of fourSCN2Avariants. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2024.02.19.580930
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