Molecular dynamics simulations reveal molecular mechanisms for the gain and loss of function effects of four SCN2A variants

Bhattarai, Nisha; Montanucci, Ludovica; Brünger, Tobias; Pérez Palma, Eduardo; Martin, William; Smith, Iris; Eng, Charis; Cheng, Feixiong; Helbig, Ingo; Müller, Rikke; Brunklaus, Andreas; Schorge, Stephanie; Lal, Dennis

Publication:
Molecular dynamics simulations reveal molecular mechanisms for the gain and loss of function effects of four SCN2A variants

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Molecular dynamics simulations reveal molecular mechanisms for the gain and loss of function effects of four SCN2A variants.pdf (3.3 MB)

Date

2024

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Article

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Artículos Medicina y Ciencias de la Salud

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27

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1

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Authors

Bhattarai, Nisha

Montanucci, Ludovica

Brünger, Tobias

Pérez Palma, Eduardo

Martin, William

Smith, Iris

Eng, Charis

Cheng, Feixiong

Helbig, Ingo

Müller, Rikke

item.page.doiurl

https://doi.org/10.1101/2024.02.19.580930

URI

https://hdl.handle.net/11447/9657

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Acceso Abierto

Abstract

SCN2A gene disorders cover a wide range of medical conditions, from epileptic encephalopathies to neurodevelopmental disorders. The variants of these disorders, studied through electrophysiology, show...

Citation

Bhattarai, N., Montanucci, L., Brünger, T., Pérez-Palma, E., Martin, W., Smith, I. N., Eng, C., Cheng, F., Helbig, I., Møller, R. S., Brunklaus, A., Schorge, S., & Lal, D. (2024). Molecular dynamics simulations reveal molecular mechanisms for the gain and loss of function effects of fourSCN2Avariants. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2024.02.19.580930

Keywords

Biophysics

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