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The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double‑blind randomised controlled trial

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dc.contributor.authorFigueroa‑Vargas, Alejandra
dc.contributor.authorGóngora, Begoña
dc.contributor.authorAlonso, María Francisca
dc.contributor.authorOrtega, Alonso
dc.contributor.authorSoto‑Fernández, Patricio
dc.contributor.authorZ‑Rivera, Lucía
dc.contributor.authorRamírez, Sebastián
dc.contributor.authorGonzález, Francisca
dc.contributor.authorMuñoz Venturelli, Paula
dc.contributor.authorBilleke, Pablo
dc.date.accessioned2024-11-25T16:56:28Z
dc.date.available2024-11-25T16:56:28Z
dc.date.issued2024
dc.description.abstractBackground The ageing population has increased the prevalence of disabling and high-cost diseases, such as dementia and mild cognitive impairment (MCI). The latter can be considered a prodromal phase of some dementias and a critical stage for interventions to postpone the impairment of functionality. Working memory (WM) is a pivotal cognitive function, representing the fundamental element of executive functions. This project proposes an intervention protocol to enhance WM in these users, combining cognitive training with transcranial electrical stimulation of alternating current (tACS). This technique has been suggested to enhance the neuronal plasticity needed for cognitive processes involving oscillatory patterns. WM stands to benefit significantly from this approach, given its well-defined electrophysiological oscillations. Therefore, tACS could potentially boost WM in patients with neurodegenerative diseases. Methods This study is a phase IIb randomised, double-blind clinical trial with a 3-month follow-up period. The study participants will be 62 participants diagnosed with MCI, aged over 60, from Valparaíso, Chile. Participants will receive an intervention combining twelve cognitive training sessions with tACS. Participants will receive either tACS or placebo stimulation in eight out of twelve training sessions. Sessions will occur twice weekly over 6 weeks. The primary outcomes will be electroencephalographic measurements through the prefrontal theta oscillatory activity, while the secondary effects will be cognitive assessments of WM. The participants will be evaluated before, immediately after, and 3 months after the end of the intervention. Discussion The outcomes of this trial will add empirical evidence about the benefits and feasibility of an intervention that combines cognitive training with non-invasive brain stimulation. The objective is to contribute tools for optimal cognitive treatment in patients with MCI. To enhance WM capacity, postpone the impairment of functionality, and obtain a better quality of life.
dc.description.versionVersión publicada
dc.format.extent14 p.
dc.identifier.citationFigueroa-Vargas A, Góngora B, Alonso MF, Ortega A, Soto-Fernández P, Z-Rivera L, Ramírez S, González F, Muñoz Venturelli P, Billeke P. The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial. Trials. 2024 Feb 23;25(1):144. doi: 10.1186/s13063-024-07972-7
dc.identifier.doihttps://doi.org/10.1186/s13063-024-07972-7
dc.identifier.urihttps://hdl.handle.net/11447/9439
dc.language.isoen
dc.subjectMild cognitive impairment
dc.subjectCognitive training
dc.subjectWorking memory
dc.subjectCognitive functions
dc.subjectNon‑invasive brain stimulation
dc.subjectRandomised controlled trial
dc.titleThe effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double‑blind randomised controlled trial
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceTrials
dspace.entity.typePublication
relation.isAuthorOfPublication918d576e-0c4f-4436-b54f-58e78c61e23a
relation.isAuthorOfPublication.latestForDiscovery918d576e-0c4f-4436-b54f-58e78c61e23a

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