Person: Apablaza, Mauricio
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Apablaza
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Mauricio
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Publication Factors influencing neutralizing antibody response to the original SARS-CoV-2 virus and the Omicron variant in a high vaccination coverage country, a population-based study(2023) Hormazabal, Juan; Nuñez-Franz, Loreto; Rubilar, Paola; Apablaza, Mauricio; Vial Cox, María Cecilia; Cortes Salinas, Lina Jimena; González, Natalia; Vial, Pablo; Said, Macarena; Gonzalez Wiedmaier, Claudia; Olivares, Kathya; Aguilera, Ximena; Ramírez-Santana, MurielThe study compared immunity to the original SARS-CoV-2 virus (Wuhan) and the Omicron variant using neutralizing antibodies (NAbs), that provide a good approximation of protective immunity. The results might help determine immunization strategies. Design and methods: Unlike previous studies, we analyzed NAbs in a random sample of 110 IgG positive sera from individuals who participated in a population-based seroprevalence transversal study, carried out in May 2022 in two Chilean cities, a country with high vaccination coverage. Results: Our findings indicate that 98.2% of individuals had NAbs against Wuhan, 65.5% against Omicron, and 32.7% tested positive for Wuhan but not Omicron. Factors influencing protective immunity included a prior natural infection and the number of vaccines received. NAbs titers against the original virus were high, demonstrating vaccine effectiveness in the population. However, the level of antibodies decreased when measuring NAbs against Omicron, particularly among older individuals, indicating a decline in vaccine protection. Previous COVID-19 episodes acted as a natural booster, increasing NAbs titers against both virus strains. Conclusions: Protective immunity against the original Wuhan SARS-CoV-2 virus is reduced when compared to Omicron variant. Updating vaccine to target emerging variants and continued monitoring of effectiveness at the population level are necessary.Publication “As if it were home”: An exploratory study of the role of homesickness among migrant entrepreneurs(2023) Poblete, Carlos; Mandakovic, Vesna; Apablaza, MauricioA common pattern observed in the psychological literature on migrants is homesickness, yet there is a lack of research examining if this phenomenon has any effect in the entrepreneurship sphere. This study begins to fill this gap with an inductive approach examining the Venezuelan migratory wave in Chile. Methodologically, we conduct an oral history analysis of 18 Venezuelan entrepreneurs’ narratives to explore the reasons they built their entrepreneurial ventures and the mechanisms underlying this process. Based on our findings, we show that homesickness can become an enabler that links entrepreneurs with a (latent unsatisfied) demand by facilitating the entrepreneurial ideation process. This phenomenon occurs because the engagement between individuals is heightened when they experience homesickness. On the one hand, we notice that homesick entrepreneurs enhance three resources that contribute to the entrepreneurial ideation process: (1) rhetorical skills, (2) affective empathy, and (3) adaptive attitude. On the other hand, two features also facilitate interaction from the demand side: (1) customer persona and (2) cohesive community identity. Thus, our results suggest that migrant entrepreneurs gain trusted partners based on shared homesickness. Consequently, a more efficient and effective entrepreneurial ideation process is generated.