Browsing by Author "Valenzuela, Romina"
Now showing 1 - 3 of 3
Results Per Page
Sort Options
Item A prospective, multi-center study of Candida bloodstream infections in Chile(2019) Santolaya, Maria E.; Thompson, Luis; Tapia, Cecilia; Legarraga, Paulette; Cortés, Claudia; Rabello, Marcela; Valenzuela, Romina; Rojas, Pamela; Rabagliati, RicardoBackground Active surveillance is necessary for improving the management and outcome of patients with candidemia. The aim of this study was to describe epidemiologic and clinical features of candidemia in children and adults in tertiary level hospitals in Chile. Methods We conducted a prospective, multicenter, laboratory-based survey study of candidemia in 26 tertiary care hospitals in Chile, from January 2013 to October 2017. Results A total of 780 episodes of candidemia were included, with a median incidence of 0.47/1,000 admissions. Demographic, clinical and microbiological information of 384 cases of candidemia, from 18 hospitals (7,416 beds), was included in this report. One hundred and thirty-four episodes (35%) occurred in pediatric patients and 250 (65%) in adult population. Candida albicans (39%), Candida parapsilosis (30%) and Candida glabrata (10%) were the leading species, with a significant difference in the distribution of species between ages. The use of central venous catheter and antibiotics were the most frequent risk factors in all age groups (> 70%). Three hundred and fifteen strains were studied for antifungal susceptibility; 21 strains (6.6%) were resistant to fluconazole, itraconazole, voriconazole, anidulafungin or micafungin. The most commonly used antifungal therapies were fluconazole (39%) and echinocandins (36%). The overall 30-day survival was 74.2%, significantly higher in infants (82%) and children (86%) compared with neonates (72%), adults (71%) and elderly (70%). Conclusions Our prospective, multicenter surveillance study showed a low incidence of candidemia in Chile, with high 30-day survival, a large proportion of elderly patients, C. glabrata as the third most commonly identified strain, a 6.6% resistance to antifungal agents and a frequent use of echinocandins.Item Corrigendum: Helicobacter pylori cagA+ Is Associated with Milder Duodenal Histological Changes in Chilean Celiac Patients(2017) Lucero, Yalda; Oyarzún, Amaya; O’Ryan, Miguel; Quera, Rodrigo; Espinosa, Nelly; Valenzuela, Romina; Simian, Daniela; Alcalde, Elisa; Arce, Claudio; Farfán, Mauricio J; Vergara, Alejandra F; Gajardo, Iván; Mendez, Jocelyn; Carrasco, Jorge; Errázuriz, Germán; González, Mónica; Ossa, Juan C; Maiza, Eduardo; Perez-Bravo, Francisco; Castro, Magdalena; Araya, MagdalenaIn the published article, there was an error in affiliation (2). Instead of “Microbiology and Micology Program, Faculty of Medicine, University of Chile, Santiago, Chile,” it should be “Microbiology and Micology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile.” The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. Additionally, there was an error regarding the affiliations for Yalda Lucero. Affiliation 8 has been removed and the following affiliation has been added instead: Pediatric Gastroenterology Unit, Department of Pediatrics, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.Item Enfermedad celíaca, sensibilidad no celíaca al gluten y alergia al trigo: comparación de patologías diferentes gatilladas por un mismo alimento(Sociedad Chilena de Pediatría, 2017) Ortiz, Catalina; Valenzuela, Romina; Lucero, YaldaGluten and other related proteins of the wheat, rye and barley, have antigenic properties that may trigger adverse reactions in susceptible individuals. Celiac disease was the first pathology with clear causal association related to the intake of these proteins. Recently, wheat allergy and non celiac gluten sensitivity have been described. Although, clinical presentation and its relation with protein ingestion may be similar and elicit confusion, their pathogenic mechanism, diagnosis and treatment are quite different. Since the prevalence of these diseases is relatively high as a whole, it is essential that these become familiar to primary care doctors and general pediatricians, thus they will know how to differentiate and face them. The aim of this review is to compare the main aspects of epidemiology, pathofisiology, diagnosis and treatment of these 3 conditions.