Browsing by Author "Outeiro, Tiago Fleming"
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Publication Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria(2023) KLEIN, ANDRES; Outeiro, Tiago Flemingβ-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly described role of GCase in the mitochondria will inform new Parkinson’s and Gaucher’s disease therapeutics.