Duration of untreated psychosis and acute remission of negative symptoms in a South American first-episode psychosis cohort.

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dc.contributor.authorGonzález-Valderrama, Alfonso
dc.contributor.authorCastañeda, Carmen Paz
dc.contributor.authorMena, Cristián
dc.contributor.authorUndurraga, Juan
dc.contributor.authorMondaca, Pilar
dc.contributor.authorYáñez, Matías
dc.contributor.authorBedregal, Paula
dc.contributor.authorNachar, Rubén
dc.date.accessioned2016-05-23T18:19:36Z
dc.date.available2016-05-23T18:19:36Z
dc.date.issued2015
dc.description.abstractAIM: To determine the association between duration of untreated psychosis (DUP) and symptoms remission in a hospitalized first-episode psychosis cohort. METHODS: Inpatients with a first-episode non-affective psychosis were recruited. Subjects were divided into two groups of long and short DUP using a 3-month cut-off point, and this was related to remission at 10 weeks of treatment. Multivariate analyses were performed. RESULTS: Fifty-five inpatients were included. There were no differences in remission rates of positive symptoms. Up to 76.5% of the patients with a short DUP (<3 months) achieved remission of negative symptoms versus 31.6% in the DUP ≥ 3 months group (P = 0.003). After controlling for relevant factors, patients with a shorter DUP were still three times more likely to achieve negative symptoms remission (HR: 3.04, 95% CI 1.2-7.5). CONCLUSIONS: DUP is a prognostic factor that should be considered at an early stage to identify a 'high risk' subgroup of persistent negative symptoms.
dc.identifier.citationGonzález-Valderrama A, Castañeda CP, Mena C, Undurraga J, Mondaca P, Yañez M, Bedregal P, Nachar R. Duration of untreated psychosis and acute remission of negative symptoms in a South American first-episode psychosis cohort. Early Interv Psychiatry. 2017 Feb;11(1):77-82.
dc.identifier.urihttp://hdl.handle.net/11447/314
dc.identifier.urihttp://dx.doi.org/10.1111/eip.12266
dc.language.isoen_US
dc.publisherWiley Publishing Asia Pty Ltd.
dc.subjectDuration of untreated psychosis
dc.subjectEarly intervention
dc.subjectNegative symptom
dc.subjectPsychosis
dc.subjectSchizophrenia
dc.titleDuration of untreated psychosis and acute remission of negative symptoms in a South American first-episode psychosis cohort.
dc.typeArtículo

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