Current Treatments and New Possible Complementary Therapies for Epithelial Ovarian Cancer

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dc.contributor.authorGarrido, Maritza
dc.contributor.authorFredes, Allison
dc.contributor.authorLobos-González, Lorena
dc.contributor.authorValenzuela, Manuel
dc.contributor.authorVera, Daniela
dc.contributor.authorRomero, Carmen
dc.date.accessioned2022-03-23T19:45:04Z
dc.date.available2022-03-23T19:45:04Z
dc.date.issued2022
dc.description.abstract: Epithelial ovarian cancer (EOC) is one of the deadliest gynaecological malignancies. The late diagnosis is frequent due to the absence of specific symptomatology and the molecular complexity of the disease, which includes a high angiogenesis potential. The first-line treatment is based on optimal debulking surgery following chemotherapy with platinum/gemcitabine and taxane compounds. During the last years, anti-angiogenic therapy and poly adenosine diphosphate-ribose polymerases (PARP)-inhibitors were introduced in therapeutic schemes. Several studies have shown that these drugs increase the progression-free survival and overall survival of patients with ovarian cancer, but the identification of patients who have the greatest benefits is still under investigation. In the present review, we discuss about the molecular characteristics of the disease, the recent evidence of approved treatments and the new possible complementary approaches, focusing on drug repurposing, non-coding RNAs, and nanomedicine as a new method for drug deliveryes
dc.description.versionVersión publicadaes
dc.identifier.citationGarrido, M.P.; Fredes, A.N.; Lobos-González, L.; ValenzuelaValderrama, M.; Vera, D.B.; Romero, C. Current Treatments and New Possible Complementary Therapies for Epithelial Ovarian Cancer. Biomedicines 2022, 10, 77. https://doi.org/10.3390/ biomedicines10010077es
dc.identifier.urihttps://doi.org/10.3390/ biomedicines10010077es
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/5784
dc.language.isoenes
dc.subjectepithelial ovarian canceres
dc.subjectdrug repurposinges
dc.subjectnon-coding RNAses
dc.subjectnanocarrierses
dc.subjectanti-angiogenic therapyes
dc.titleCurrent Treatments and New Possible Complementary Therapies for Epithelial Ovarian Canceres
dc.typeArticlees
dcterms.sourceBiomedicineses

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