Extracellular Cysteine in Connexins: Role as Redox Sensors

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dc.contributor.authorRetamal, Mauricio
dc.contributor.authorGarcía, Isaac
dc.contributor.authorPinto, Bernardo
dc.contributor.authorPupo, Amaury
dc.contributor.authorBáez, David
dc.contributor.authorStehberg, Jimmy
dc.contributor.authorDel Río, Rodrigo
dc.contributor.authorGonzález, Carlos
dc.date.accessioned2017-01-03T15:07:56Z
dc.date.available2017-01-03T15:07:56Z
dc.date.issued2016
dc.descriptionCentro de Fisiología Celular e Integrativa
dc.description.abstractConnexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa. Similarly, the opening of gap junction channels permits the diffusional exchange of ions and molecules between the cytoplasm and contacting cells. The controlled opening of hemichannels has been associated with several physiological cellular processes; thereby unregulated hemichannel activity may induce loss of cellular homeostasis and cell death. Hemichannel activity can be regulated through several mechanisms, such as phosphorylation, divalent cations and changes in membrane potential. Additionally, it was recently postulated that redox molecules could modify hemichannels properties in vitro. However, the molecular mechanism by which redox molecules interact with hemichannels is poorly understood. In this work, we discuss the current knowledge on connexin redox regulation and we propose the hypothesis that extracellular cysteines could be important for sensing changes in redox potential. Future studies on this topic will offer new insight into hemichannel function, thereby expanding the understanding of the contribution of hemichannels to disease progression.
dc.identifier.citationFrontiers in Physiology, January 2016, vol.7, p.1
dc.identifier.urihttp://hdl.handle.net/11447/910
dc.identifier.urihttp://dx.doi.org/ 10.3389/fphys.2016.00001
dc.language.isoen_US
dc.publisherLausanne : Frontiers Research Foundation
dc.subjectConnexins
dc.subjectHemichannels
dc.subjectRedox potential
dc.subjectGap junction channels
dc.subjectPost-translational modification
dc.subjectGaseous transmitters
dc.titleExtracellular Cysteine in Connexins: Role as Redox Sensors
dc.typeArtículo

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