Receptors involved in dexketoprofen analgesia in murine visceral pain

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dc.contributor.authorNoriega, Viviana
dc.contributor.authorSierralta, Fernando
dc.contributor.authorAranda, Nicolás
dc.contributor.authorSotomayor, Ramón
dc.contributor.authorPrieto, Juan
dc.contributor.authorMiranda, Hugo
dc.contributor.authorPoblete, P.
dc.date.accessioned2022-06-23T14:26:01Z
dc.date.available2022-06-23T14:26:01Z
dc.date.issued2020
dc.description.abstractVarious animal models, especially rodents, are used to study pain, due to the difficulty of studying it in humans. Many drugs that produce analgesia have been studied and there is evidence among which NSAIDs deserve to be highlighted. Dexketoprofen (DEX) provides a broad antinociceptive profile in different types of pain; therefore, this study was designed to evaluate the profile of antinociceptive potency in mice. Analgesic activity was evaluated using the acetic acid abdominal constriction test (writhing test), a chemical model of visceral pain. Dose-response curves for i.p. DEX administration (1, 3, 10, 30 and 100 mg/kg), using at least six mice in each of at least five doses, was obtained before and 30 min after pre-treatment with different pharmacological agents. Pretreatment of the mice with opioid receptor antagonists was not effective; however, the serotonin receptor antagonist and nitric oxide synthase inhibitor produce a significant increase in DEX-induced antinociception. The data from the present study shows that DEX produces antinociception in the chemical twisting test of mice, which is explained with difficulty by the simple inhibition of COX. This effect appears to be mediated by other mechanisms in which the contribution of the NO and 5-HT pathways has an important effect on DEX- induced antinociception.es
dc.description.versionVersión publicadaes
dc.identifier.citationNoriega V, Sierralta F, Poblete P, Aranda N, Sotomayor-Zarate R, Prieto JC, Miranda HF. Receptors involved in dexketoprofen analgesia in murine visceral pain. J Biosci. 2020;45:94. https://10.1007/s12038-020-00064-zes
dc.identifier.urihttps://doi.org/10.1007/s12038-020-00064-zes
dc.identifier.urihttp://hdl.handle.net/11447/6249
dc.language.isoenes
dc.subjectDexketoprofenes
dc.subjectReceptor antagonistses
dc.subjectViscerales
dc.subjectWrithing testes
dc.titleReceptors involved in dexketoprofen analgesia in murine visceral paines
dc.typeArticlees
dcterms.sourceJournal of bioscienceses

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