Selective digestive decontamination with oral colistin plus gentamicin for persistent bacteraemia caused by non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae in a neutropenic patient
Date
2021
Type:
Article
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Abstract
Carbapenem-resistant Klebsiella pneumoniae (CRKp) have become an increasing public health problem worldwide. While most CRKp around the world harbour a carbapenemase enzyme, the clinical relevance of non-carbapenemase-producing CRKp (non-CP-CRKp) is increasingly recognized. Selective digestive decontamination (SDD) has been proven successful as a decolonization strategy for patients colonized with Gram-negatives in the ICU. However, it is not regularly used to treat invasive infections.
Description
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Citation
Maria Spencer-Sandino, Roberto Riquelme-Neira, William C Shropshire, An Q Dinh, Gerardo González-Rocha, Paulina González-Muñoz, Alejandra Vera-Leiva, Rafael Araos, Blake Hanson, Cesar A Arias, José M Munita, Descontaminación digestiva selectiva con colistina oral más gentamicina para la bacteriemia persistente causada por Klebsiella pneumoniae resistente a los carbapenemas no productora de carbapenemasas en un paciente neutropénico, JAC-Resistencia a los antimicrobianos , volumen 3, número 2, junio de 2021, dlab079, https://doi.org/10.1093 /jacamr/dlab079
Keywords
phenotype, gentamicin sulfate, bacteremia, neutropenia, gentamicins, gene amplification, gastrointestinal system, intensive care unit, intestines, klebsiella pneumoniae, microbial colonization, bloodstream infections, digestive tract decontamination, carbapenem resistance