New Pharmacological Strategies for the Treatment of Non-Infectious Uveitis. A Minireview

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dc.contributor.authorValenzuela, Rodrigo A.
dc.contributor.authorFlores, Iván
dc.contributor.authorUrrutia, Beatríz
dc.contributor.authorFuentes, Francisca
dc.contributor.authorSabat, Pablo E.
dc.contributor.authorLlanos, Carolina
dc.contributor.authorCuitino, Loreto
dc.contributor.authorUrzúa, Cristhian
dc.date.accessioned2021-07-14T19:36:57Z
dc.date.available2021-07-14T19:36:57Z
dc.date.issued2020-05
dc.description.abstractNon-infectious uveitis (NIU) is a group of disorders characterized by intraocular inflammation at different levels of the eye. NIU is a leading cause of irreversible blindness in working-age population in the developed world. The goal of uveitis treatment is to control inflammation, prevent recurrences, and preserve vision, as well as minimize the adverse effects of medications. Currently, the standard of care for NIU includes the administration of corticosteroids (CS) as first-line agents, but in some cases a more aggressive therapy is required. This includes synthetic immunosuppressants, such as antimetabolites (methotrexate, mycophenolate mofetil, and azathioprine), calcineurinic inhibitors (cyclosporine, tacrolimus), and alkylating agents (cyclophosphamide, chlorambucil). In those patients who become intolerant or refractory to CS and conventional immunosuppressive treatment, biologic agents have arisen as an effective therapy. Among the most evaluated treatments, TNF-α inhibitors, IL blockers, and anti-CD20 therapy have emerged. In this regard, anti-TNF agents (infliximab and adalimumab) have shown the strongest results in terms of favorable outcomes. In this review, we discuss latest evidence concerning to the effectiveness of biologic therapy, and present new therapeutic approaches directed against immune components as potential novel therapies for NIU.es
dc.identifier.citationFrontiers in Pharmacology, 2020, vol.11, art. 655es
dc.identifier.urihttps://doi.org/10.3389/fphar.2020.00655es
dc.identifier.urihttp://hdl.handle.net/11447/4185
dc.language.isoenes
dc.subjectUveitises
dc.subjectIntraocular inflammationes
dc.subjectBiologicses
dc.subjectAnti-tumor necrosis factores
dc.subjectTreatmentes
dc.titleNew Pharmacological Strategies for the Treatment of Non-Infectious Uveitis. A Minireviewes
dc.typeArticlees

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