Bullous Henoch-Schönlein purpura. Case report

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dc.contributor.authorHasbún, Trinidad
dc.contributor.authorChaparro, Ximena
dc.contributor.authorKaplan, Viera
dc.contributor.authorCavagnaro, Felipe
dc.contributor.authorCastro, Alex
dc.date.accessioned2022-05-02T22:37:37Z
dc.date.available2022-05-02T22:37:37Z
dc.date.issued2018
dc.description.abstractHenoch- Schönlein purpura (HSP) or IgA Vasculitis is the most common childhood vasculitis. The classic tetrad of signs and symptoms include palpable purpura, arthralgia, abdominal pain and renal disease. The occurrence of hemorrhagic bullae in children with HSP is rarely encountered. Objective: To report an unusual cutaneous manifestation of HSP in children. Case report: A 14-year-old girl complained about a 2-week painful bullous rash in both lower extremities and multiple arthralgias. There was no history of abdominal pain or urinary symptoms. In both lower extremities, there were numerous palpable purpura and hemmorrhagic bullae. In light of clinical findings, laboratory tests and skin biopsy are requested. The histopathology described intraepidermal blisters, acanthosis, spongiosis and perivascular dermal infiltrate. Direct immunofluorescence (IFD) (+) for IgA. The diagnosis of bullous HSP was made and treatment with endovenous corticosteroids was initiated. Three days after overlapping to oral corticosteroids, new ecchymotic lesions appeared in both legs. Due to the persistence of cutaneous involvement and negative control tests, azathioprine was associated obtaining a good response. Conclusion: Although bullous lesions in HSP does not add morbidity, it is often an alarming phenomenon with multiple differential diagnoses. The anti-inflamatory effect of corticoids is likely to be beneficial in the treatment of patients with severe cutaneous involvement through inhibition of proinflammatory transcription factors and decreasing the production of the metalloproteinases.es
dc.description.versionVersión Publicadaes
dc.identifier.citationHasbún Trinidad, Chaparro Ximena, Kaplan Viera, Cavagnaro Felipe, Castro Alex. Bullous Henoch-Schönlein purpura. Case report. Rev. chil. pediatr. [Internet]. 2018 Feb [cited 2022 May 02] ; 89( 1 ): 103-106. Available from: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0370-41062018000100103&lng=en. http://dx.doi.org/10.4067/S0370-41062018000100103.es
dc.identifier.urihttps://doi.org/10.4067/S0370-41062018000100103es
dc.identifier.urihttp://hdl.handle.net/11447/6045
dc.language.isoenes
dc.subjectSchönlein Henoches
dc.subjectVasculitises
dc.subjectBlisterses
dc.subjectBullous purpuraes
dc.titleBullous Henoch-Schönlein purpura. Case reportes
dc.title.alternativePúrpura de Schönlein-Henoch Buloso. Caso clínicoes
dc.typeArticlees
dcterms.sourceRevista Chilena de Pediatríaes

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