Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute Intracerebral Hemorrhage: Results of the INTERACT Studies

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dc.contributor.authorChan, Edward
dc.contributor.authorAnderson, Craig
dc.contributor.authorWang, Xia
dc.contributor.authorArima, Hisatomi
dc.contributor.authorSaxena, Anubhav
dc.contributor.authorMoullaali, Tom
dc.contributor.authorDelcourt, Candice
dc.contributor.authorWu, Guojun
dc.contributor.authorWang, Jinchao
dc.contributor.authorChen, Guofang
dc.contributor.authorLavados, Pablo
dc.contributor.authorStampf, Christian
dc.contributor.authorRobinson, Thompson
dc.contributor.authorChalmers, John
dc.date.accessioned2017-08-16T19:43:01Z
dc.date.available2017-08-16T19:43:01Z
dc.date.issued2016
dc.description.abstractBackground Intraventricular hemorrhage (IVH) extension is common following acute intracerebral hemorrhage (ICH) and is associated with poor prognosis. Aim To determine whether intensive blood pressure (BP)-lowering therapy reduces IVH growth. Methods Pooled analyses of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials (INTERACT1 and INTERACT2) computed tomography (CT) substudies; multicenter, open, controlled, randomized trials of patients with acute spontaneous ICH and elevated systolic BP, randomly assigned to intensive (<140 mm Hg) or guideline-based (<180 mm Hg) BP management. Participants had blinded central analyses of baseline and 24-hour CT. Association of BP lowering to IVH growth was assessed in analysis of covariance. Results There was no significant difference in adjusted mean IVH growth following intensive (n = 228) compared to guideline-recommended (n = 228) BP treatment (1.6 versus 2.2 ml, respectively; p = 0.56). Adjusted mean IVH growth was nonsignificantly greater in patients with a mean achieved systolic BP ≥160 mm Hg over 24 h (3.94 ml; p trend = 0.26). Conclusions Early intensive BP-lowering treatment had no clear effect on IVH in acute ICH.
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dc.identifier.citationChan E, Anderson C, S, Wang X, Arima H, Saxena A, Moullaali T, J, Delcourt C, Wu G, Wang J, Chen G, Lavados P, M, Stapf C, Robinson T, Chalmers J: Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute Intracerebral Hemorrhage: Results of the INTERACT Studies. Cerebrovasc Dis Extra 2016;6:71-75.
dc.identifier.urihttp://hdl.handle.net/11447/1583
dc.identifier.urihttp://dx.doi.org/10.1159/000448897
dc.language.isoen_US
dc.publisherKarger
dc.subjectStroke
dc.subjectIntracerebral hemorrhage
dc.subjectIntraventricular hemorrhage
dc.subjectHypertension
dc.subjectIntensive blood pressure lowering
dc.titleEarly Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute Intracerebral Hemorrhage: Results of the INTERACT Studies
dc.typeArtículo

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