Angiotensin-converting enzyme insertion/deletion polymorphism is associated with severe hypoxemia in pediatric ARDS

Simple item page
dc.contributor.authorCruces, Pablo
dc.contributor.authorPuga, Alonso
dc.contributor.authorErranz, Benjamín
dc.contributor.authorDonoso, Alejandro
dc.contributor.authorCarvajal, Cristobal
dc.contributor.authorWilhelm, Jan
dc.contributor.authorRepetto, Gabriela
dc.date.accessioned2017-05-29T17:10:48Z
dc.date.available2017-05-29T17:10:48Z
dc.date.issued2012
dc.descriptionCentro de Genética y Genómica
dc.description.abstractPURPOSE: The D allele of the insertion/deletion (I/D) polymorphism of a 287-bp sequence in the angiotensin-converting enzyme (ACE) gene has been associated with an increased activity of this enzyme. Its role in susceptibility to acute respiratory distress syndrome (ARDS) has not been well defined. We hypothesized that ACE I/D genotype in pediatrics is associated with ARDS and plasma levels of angiotensin II. METHODS: Prospective case-control study in patients under 15 years of age from a mixed Chilean population. Sixty patients with ARDS and 60 controls were included. Association between ACE genotype and ARDS was evaluated as the primary outcome; mortality and severe hypoxemia were examined as secondary outcomes. Plasma angiotensin-II concentration was measured by immunoassay at admission. RESULTS: Frequency of ACE I/D genotype was similar in ARDS and control groups (p = 0.18). In the ARDS group, severe hypoxemia was less frequent in D allele carriers (p < 0.05). Plasma angiotensin-II levels were associated with genotype in the ARDS group, but not controls, being higher in D allele carriers (p = 0.016). CONCLUSION: These data do not support the association between ACE I/D genotype and ARDS, although severe hypoxemia was less frequent in D allele carriers. ACE I/D polymorphism modified angiotensin-II levels in pediatric ARDS, but its pathogenic role is not well understood and needs to be addressed in future studies.
dc.format.extent7
dc.identifier.citationIntensive Care Med. 2012 Jan;38(1):113-9
dc.identifier.urihttp://hdl.handle.net/11447/1360
dc.identifier.urihttp://dx.doi.org/10.1007/s00134-011-2381-3
dc.language.isoen_US
dc.publisherSpringer
dc.subjectAngiotensin-converting enzyme
dc.subjectAngiotensin II
dc.subjectAcute respiratory distress syndrome
dc.subjectGenetic polymorphism
dc.subjectPediatrics
dc.titleAngiotensin-converting enzyme insertion/deletion polymorphism is associated with severe hypoxemia in pediatric ARDS
dc.typeArtículo

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Angiotensin-converting enzyme insertion deletion polymorphism is associated with severe hypoxemia in pediatric ARDS.pdf
Size:
232.91 KB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services