Nitric oxide signaling in the retina: What have we learned in two decades?

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dc.contributor.authorVielma, Alex H.
dc.contributor.authorRetamal, Mauricio A.
dc.contributor.authorSchmachtenberg, Oliver
dc.date.accessioned2021-10-04T15:13:11Z
dc.date.available2021-10-04T15:13:11Z
dc.date.issued2012
dc.description.abstractTwo decades after its first detection in the retina, nitric oxide (NO) continues to puzzle visual neuroscientists. While its liberation by photoreceptors remains controversial, recent evidence supports three subtypes of amacrine cells as main sources of NO in the inner retina. NO synthesis was shown to depend on light stimulation, and mounting evidence suggests that NO is a regulator of visual adaptation at different signal processing levels. NO modulates light responses in all retinal neuron classes, and specific ion conductances are activated by NO in rods, cones, bipolar and ganglion cells. Light-dependent gap junction coupling in the inner and outer plexiform layers is also affected by NO. The vast majority of these effects were shown to be mediated by activation of the NO receptor soluble guanylate cyclase and resultant cGMP elevation. This review analyzes the current state of knowledge on physiological NO signaling in the retina.es
dc.identifier.citationBrain research, 2012, 1430:112-25es
dc.identifier.urihttp/dx.doi.org/10.1016/j.brainres.2011.10.045es
dc.identifier.urihttp://hdl.handle.net/11447/4779
dc.language.isoenes
dc.subjectCell Communication / physiologyes
dc.subjectNitrergic Neurons / metabolismes
dc.subjectNitric Oxide / physiologyes
dc.subjectRetina / cytologyes
dc.subjectRetina / physiologyes
dc.subjectSignal Transduction / physiologyes
dc.titleNitric oxide signaling in the retina: What have we learned in two decades?es
dc.typeArticlees

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