A normative chart for cognitive development in a genetically selected population

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dc.contributor.authorFiksinski, Ania
dc.contributor.authorBearden, Carrie
dc.contributor.authorBassett, Anne
dc.contributor.authorKahn, René
dc.contributor.authorZinkstok, Janneke
dc.contributor.authorHooper, Stephen R
dc.contributor.authorTempelaar, Wanda
dc.contributor.authorMcDonald, Donna
dc.contributor.authorSwillen, Ann
dc.contributor.authorEmanuel, Beverly
dc.contributor.authorMorrow, Bernice
dc.contributor.authorGur, Raquel
dc.contributor.authorChow, Eva
dc.contributor.authorVan den Bree, Marianne
dc.contributor.authorVermeesch, Joris
dc.contributor.authorWarren, Stephen
dc.contributor.authorOwen, Michael
dc.contributor.authorVan Amelsvoort, Therese
dc.contributor.authorEliez, Stephan
dc.contributor.authorGothelf, Doron
dc.contributor.authorArango, Celso
dc.contributor.authorKates, Wendy
dc.contributor.authorSimon, Tony
dc.contributor.authorMurphy, Kieran
dc.contributor.authorRepetto, Gabriela
dc.contributor.authorHeine, Damian
dc.contributor.authorVicari, Stefano
dc.contributor.authorCubells, Joseph
dc.contributor.authorArmando, Marco
dc.contributor.authorPhilip, Nicole
dc.contributor.authorCampbell, Linda
dc.contributor.authorGarcía, Sixto
dc.contributor.authorSchneider, Maude
dc.contributor.authorShashi, Vandana
dc.contributor.author22q11DS International Consortium on Brain and Behavior
dc.contributor.authorVorstman, Jacob
dc.contributor.authorBreetvelt, Elemi
dc.date.accessioned2022-03-30T13:26:16Z
dc.date.available2022-03-30T13:26:16Z
dc.date.issued2021
dc.description.abstractCertain pathogenic genetic variants impact neurodevelopment and cause deviations from typical cognitive trajectories. Understanding variant-specific cognitive trajectories is clinically important for informed monitoring and identifying patients at risk for comorbid conditions. Here, we demonstrate a variant-specific normative chart for cognitive development for individuals with 22q11.2 deletion syndrome (22q11DS). We used IQ data from 1365 individuals with 22q11DS to construct variant-specific normative charts for cognitive development (Full Scale, Verbal, and Performance IQ). This allowed us to calculate Z-scores for each IQ datapoint. Then, we calculated the change between first and last available IQ assessments (delta Z-IQ-scores) for each individual with longitudinal IQ data (n = 708). We subsequently investigated whether using the variant-specific IQ-Z-scores would decrease required sample size to detect an effect with schizophrenia risk, as compared to standard IQ-scores. The mean Z-IQ-scores for FSIQ, VIQ, and PIQ were close to 0, indicating that participants had IQ-scores as predicted by the normative chart. The mean delta-Z-IQ-scores were equally close to 0, demonstrating a good fit of the normative chart and indicating that, as a group, individuals with 22q11DS show a decline in IQ-scores as they grow into adulthood. Using variant-specific IQ-Z-scores resulted in 30% decrease of required sample size, as compared to the standard IQ-based approach, to detect the association between IQ-decline and schizophrenia (p < 0.01). Our findings suggest that using variant-specific normative IQ data significantly reduces required sample size in a research context, and may facilitate a more clinically informative interpretation of IQ data. This approach allows identification of individuals that deviate from their expected, variant-specific, trajectory. This group may be at increased risk for comorbid conditions, such as schizophrenia in the case of 22q11DS.es
dc.description.versionVersión publicadaes
dc.identifier.citationFiksinski AM, Bearden CE, Bassett AS, Kahn RS, Zinkstok JR, Hooper SR, Tempelaar W, McDonald-McGinn D, Swillen A, Emanuel B, Morrow B, Gur R, Chow E, van den Bree M, Vermeesch J, Warren S, Owen M, van Amelsvoort T, Eliez S, Gothelf D, Arango C, Kates W, Simon T, Murphy K, Repetto G, Suner DH, Vicari S, Cubells J, Armando M, Philip N, Campbell L, Garcia-Minaur S, Schneider M, Shashi V; 22q11DS International Consortium on Brain and Behavior, Vorstman J, Breetvelt EJ. A normative chart for cognitive development in a genetically selected population. Neuropsychopharmacology. 2021 Mar 29. doi: 10.1038/s41386-021-00988-6es
dc.identifier.urihttps://doi.org/10.1038/s41386-021-00988-6es
dc.identifier.urihttp://hdl.handle.net/11447/5854
dc.language.isoenes
dc.subjectAdolescentes
dc.subjectAge Factorses
dc.subjectChildes
dc.subjectCognition Disorders / complicationses
dc.subjectCognition Disorders / psychologyes
dc.subjectHumanses
dc.subjectIntelligence Testses
dc.subjectNeuropsychological Testses
dc.subjectPsychotic Disorders / complicationses
dc.subjectPsychotic Disorders / psychologyes
dc.subjectCognitive developmentes
dc.titleA normative chart for cognitive development in a genetically selected populationes
dc.typeArticlees
dcterms.sourceNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacologyes

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