Impact of arsenic exposure on clinicopathological characteristics of bladder cancer: A comparative study between patients from an arsenic-exposed region and nonexposed reference sites

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dc.contributor.authorFernández, Mario
dc.contributor.authorValdebenito, Patricio
dc.contributor.authorDelgado, Iris
dc.contributor.authorSegebre, Jorge
dc.contributor.authorChaparro, Eduardo
dc.contributor.authorFuentealba, David
dc.contributor.authorCastillo, Martín
dc.contributor.authorVial, Cecilia
dc.contributor.authorBarroso, Juan
dc.contributor.authorZiegler, Annemarie
dc.contributor.authorBustamante, Alberto
dc.date.accessioned2020-09-07T19:06:15Z
dc.date.available2020-09-07T19:06:15Z
dc.date.issued2020-02
dc.description.abstractBackground: Beyond exposure to arsenic in drinking-water, there is few information about demographic and clinicopathological features of patients with bladder cancer living in arsenic-exposed regions. The aim of the study was to assess the impact of arsenic exposure on clinicopathological characteristics in patients with bladder cancer from a contaminated region compared to those of 2 reference areas. Methods: Data of 285 patients with bladder cancer (83 with arsenic exposure from Antofagasta and 202 controls from 2 different sites in Santiago) were obtained through personal interviews and from review of medical records. Demographic, clinicopathological parameters, and information on relevant environmental risk factors were compared with parametric and nonparametric tests as needed. Multivariable analysis was performed to identify independent predictors for high grade and muscle-invasive disease (T2-4). Results: We found no significant differences between groups regarding age at presentation (66.4 vs. 66.5 and 67.2 years; P = 0.69, for exposed vs. the 2 nonexposed groups, respectively) and female gender (28.9% vs. 29.8% and 26.2%; P = 0.84). Proportion of current smokers was significantly lower in the exposed population (10.7% vs. 38.6% and 26.9%; P < 0.001). There was a significantly higher proportion of locally advanced (10.8 vs. 1.8 and 0.7% T3/4; P = 0.002) and high-grade tumors (79.5% vs. 63.2% and 64.1%; P = 0.001) within arsenic-exposed patients. Arsenic exposure was the only significant predictor for the presence of high-grade tumors (adjusted OR: 5.10; 95%CI: 2.03-12.77) on multivariable analysis. Conclusions: Our study revealed relevant clinical differences in bladder cancer patients with a history of arsenic exposure as compared to nonexposed cases. The more aggressive phenotype associated to arsenic-related bladder cancer should be considered when designing efficient screening strategies for this high-risk population.es
dc.identifier.citationFernández MI, Valdebenito P, Delgado I, et al. Impact of arsenic exposure on clinicopathological characteristics of bladder cancer: A comparative study between patients from an arsenic-exposed region and nonexposed reference sites. Urol Oncol. 2020;38(2):40.e1-40.e7. doi:10.1016/j.urolonc.2019.09.013es
dc.identifier.urihttps://doi.org/10.1016/j.urolonc.2019.09.013es
dc.identifier.urihttp://hdl.handle.net/11447/3414
dc.language.isoenes
dc.publisherElsevier Inc.es
dc.subjectArsenices
dc.subjectCarcinogenesises
dc.subjectDrinking wateres
dc.subjectNeoplasmes
dc.subjectUrinary bladderes
dc.subjectRisk factores
dc.titleImpact of arsenic exposure on clinicopathological characteristics of bladder cancer: A comparative study between patients from an arsenic-exposed region and nonexposed reference siteses
dc.typeArticlees

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