Búsqueda del ADN del virus HTLV-1 en biopsias de pacientes con linfoma cutáneo de células T

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dc.contributor.authorBenedetto E., Juana
dc.contributor.authorMolgó N., Montserrat
dc.contributor.authorGonzález B., Sergio
dc.date.accessioned2021-11-02T15:07:51Z
dc.date.available2021-11-02T15:07:51Z
dc.date.issued2014
dc.description.abstractBackground: Human T-lymphotropic virus-1 (HTLV-1) infection has been associated with the pathogenesis of cutaneous T cell lymphomas (CTCL). Aim:To search for HTLV-1 DNA in skin biopsies of patients with CTCL. Material and Methods: A retrospective study was conducted using 25 biopsies of patients with CTCL. DNA was extracted from lymphoid tissue by microdissection. A nested PCR was conducted to detect HTLV-1 genome using primers for the tax region. As negative controls, four cases of superficial perivascular dermatitis were chosen. As positive controls, five cases of T-cell leukemia/lymphoma (ATCL) were studied. Results: A positive reaction was found in 3 of 25 cases. These biopsies corresponded to a case of Mycosis Fungoides, a case of CD30 (-) T cell lymphoma and a case of lymphomatoid papulosis. Search was negative in the four cases of superficial perivascular dermatitis and positive in four cases of adult T-cell leukemia/lymphoma (ATCL). Conclusions: HTLV-1 DNA search in tissues is a useful tool recommended to study T-cell lymphomas. HTLV-1 infection only occurs in sporadic cases but may contribute to tumor aggressiveness and prognosis.es
dc.identifier.citationRevista Médica de Chile, 2014, 142: 314-322es
dc.identifier.urihttp://dx.doi.org/10.4067/S0034-98872014000300005es
dc.identifier.urihttp://hdl.handle.net/11447/4988
dc.language.isoeses
dc.subjectT-lymphotropic virus 1es
dc.subjectLymphoma T-celles
dc.subjectCutaneouses
dc.subjectPolymerase chain reactiones
dc.titleBúsqueda del ADN del virus HTLV-1 en biopsias de pacientes con linfoma cutáneo de células Tes
dc.title.alternativeDetection of HTLV-1 DNA in biopsies of Chilean patients with cutaneous T-cell lymphomaes
dc.typeArticlees

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