Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study

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dc.contributor.authorZheng, Danni
dc.contributor.authorArima, Hisatomi
dc.contributor.authorSato, Shoichiro
dc.contributor.authorGasparrini, Antonio
dc.contributor.authorHeeley, Emma
dc.contributor.authorDelcourt, Candice
dc.contributor.authorLo, Serigne
dc.contributor.authorHuang, Yining
dc.contributor.authorWang, Jiguang
dc.contributor.authorStapf, Christian
dc.contributor.authorThompson, Robinson
dc.contributor.authorLavados, Pablo
dc.contributor.authorChalmers, John
dc.contributor.authorAnderson, Craig
dc.contributor.authorINTERACT2 Investigators
dc.date.accessioned2017-01-06T12:41:17Z
dc.date.available2017-01-06T12:41:17Z
dc.date.issued2016
dc.description.abstractBackground Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale. Methods INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150–220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI. Results Low ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99–1.91) for 10°C, 1.92 (1.31–2.81) for 0°C, 3.13 (1.89–5.19) for -10°C, and 5.76 (2.30–14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses. Conclusions Exposure to low ambient temperature within several hours increases the risk of ICH.
dc.identifier.citationZheng D, Arima H, Sato S, Gasparrini A, Heeley E, Delcourt C, Lo S, Huang Y, Wang J, Stapf C, Robinson T, Lavados P, Chalmers J, Anderson CS; INTERACT2 investigators. Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study. PLoS One. 2016 Feb 9;11(2):e0149040
dc.identifier.urihttp://hdl.handle.net/11447/933
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0149040
dc.language.isoen_US
dc.publisherPLOS
dc.subjectIntracerebral hemorrhage
dc.subjectAmbient temperature
dc.subjectRisk
dc.titleLow Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
dc.typeArtículo

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