Plasma versus Erythrocyte Vitamin E in Renal Transplant Recipients, and Duality of Tocopherol Species

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dc.contributor.authorSotomayor, Camilo
dc.contributor.authorRodrigo, Ramón
dc.contributor.authorGomes, António
dc.contributor.authorGormaz, Juan
dc.contributor.authorPol, Robert
dc.contributor.authorMinovi´c, Isidor
dc.contributor.authorEggersdorfer, Manfred
dc.contributor.authorVos, Michel
dc.contributor.authorRiphagen, Ineke
dc.contributor.authorH. de Borst, Martin
dc.contributor.authorNolte, Ilja
dc.contributor.authorBerger, Stefan
dc.contributor.authorNavis, Gerjan
dc.contributor.authorBakker, Stephan
dc.date.accessioned2022-07-05T21:12:44Z
dc.date.available2022-07-05T21:12:44Z
dc.date.issued2019
dc.description.abstractRedox imbalance is an adverse on-going phenomenon in renal transplant recipients (RTR). Vitamin E has important antioxidant properties that counterbalance its deleterious effects. However, plasma vitamin E affinity with lipids challenges interpretation of its levels. To test the hypothesis that erythrocyte membranes represent a lipids-independent specimen to estimate vitamin E status, we performed a cross-sectional study in a cohort of adult RTR (n = 113) recruited in a university setting (2015-2018). We compared crude and total lipids-standardized linear regression-derived coefficients of plasma and erythrocyte tocopherol species in relation to clinical and laboratory parameters. Strongly positive associations of fasting lipids with plasma tocopherol became inverse, rather than absent, in total lipids-standardized analyses, indicating potential overadjustment. Whilst, no variables from the lipids domain were associated with the tocopherol species measured from erythrocyte specimens. In relation to inflammatory status and clinical parameters with antioxidant activity, we found associations in directions that are consistent with either beneficial or adverse effects concerning α- or γ-tocopherol, respectively. In conclusion, erythrocytes offer a lipids-independent alternative to estimate vitamin E status and investigate its relationship with parameters over other biological domains. In RTR, α- and γ-tocopherol may serve as biomarkers of relatively lower or higher vulnerability to oxidative stress and inflammation, noticeably in opposite directions.es
dc.description.versionVersión publicadaes
dc.identifier.citationSotomayor CG, Rodrigo R, Gomes-Neto AW, Gormaz JG, Pol RA, Minović I, Eggersdorfer ML, Vos M, Riphagen IJ, de Borst MH, Nolte IM, Berger SP, Navis GJ, Bakker SJL. Plasma versus Erythrocyte Vitamin E in Renal Transplant Recipients, and Duality of Tocopherol Species. Nutrients. 2019 Nov 19;11(11):2821. doi: 10.3390/nu11112821.es
dc.identifier.urihttps://doi.org/10.3390/nu11112821es
dc.identifier.urihttp://hdl.handle.net/11447/6299
dc.language.isoenes
dc.subjectCardiovascular diseasees
dc.subjectErythrocytees
dc.subjectInflammationes
dc.subjectOxidative stresses
dc.subjectRenal transplant recipientses
dc.subjectRenal transplantationes
dc.subjectVitamin Ees
dc.subjectα-tocopheroles
dc.subjectγ-tocopheroles
dc.subjectTocopheroles
dc.titlePlasma versus Erythrocyte Vitamin E in Renal Transplant Recipients, and Duality of Tocopherol Specieses
dc.typeArticlees
dcterms.sourceNutrientses

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