Lithium treatment for unipolar major depressive disorder: Systematic review

Simple item page
dc.contributor.authorUndurraga, Juan
dc.contributor.authorKang, Sim
dc.contributor.authorTondo, Leonardo
dc.contributor.authorGorodischer, Ariel
dc.contributor.authorAzua, Emilio
dc.contributor.authorTay, Kai
dc.contributor.authorTan, David
dc.contributor.authorBaldessarini, Ross
dc.date.accessioned2020-08-31T19:33:46Z
dc.date.available2020-08-31T19:33:46Z
dc.date.issued2019-02
dc.description.abstractBackground: The potential value of lithium treatment in particular aspects of unipolar major depressive disorder remains uncertain. Methods: With reports of controlled trials identified by systematic searching of Medline, Cochrane Library, and PsycINFO literature databases, we summarized responses with lithium and controls followed by selective random-effects meta-analyses. Results: We identified 36 reports with 39 randomized controlled trials: six for monotherapy and 12 for adding lithium to antidepressants for acute major depression, and 21 for long-term treatment. Data for monotherapy of acute depression were few and inconclusive. As an adjunct to antidepressants, lithium was much more effective than placebo ( p<0.0001). For long-term maintenance treatment, lithium was more effective than placebo in monotherapy ( p=0.011) and to supplement antidepressants ( p=0.038), and indistinguishable from antidepressant monotherapy. Conclusions: The findings indicate efficacy of lithium as a treatment for some aspects of major depressive disorder, especially as an add-on to antidepressants and for long-term prophylaxis. It remains uncertain whether some benefits of lithium treatment occur with many major depressive disorder patients, or if efficacy is particular to a subgroup with bipolar disorder-like characteristics or mixed-features.es
dc.identifier.citationJ Psychopharmacol . 2019 Feb;33(2):167-176. doi: 10.1177/0269881118822161.es
dc.identifier.urihttps://doi.org/10.1177/0269881118822161es
dc.identifier.urihttp://hdl.handle.net/11447/3383
dc.language.isoenes
dc.publisherSagees
dc.subjectLithiumes
dc.subjectSystematic reviewes
dc.subjectUnipolar major depression.es
dc.titleLithium treatment for unipolar major depressive disorder: Systematic reviewes
dc.typeArticlees

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Lithium treatment for unipolar major depressive disorder Systematic review_ Undurraga JP.pdf
Size:
966.44 KB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services