A prospective, multi-center study of Candida bloodstream infections in Chile

Simple item page
dc.contributor.authorSantolaya, Maria E.
dc.contributor.authorThompson, Luis
dc.contributor.authorTapia, Cecilia
dc.contributor.authorLegarraga, Paulette
dc.contributor.authorCortés, Claudia
dc.contributor.authorRabello, Marcela
dc.contributor.authorValenzuela, Romina
dc.contributor.authorRojas, Pamela
dc.contributor.authorRabagliati, Ricardo
dc.date.accessioned2022-07-01T16:57:26Z
dc.date.available2022-07-01T16:57:26Z
dc.date.issued2019
dc.description.abstractBackground Active surveillance is necessary for improving the management and outcome of patients with candidemia. The aim of this study was to describe epidemiologic and clinical features of candidemia in children and adults in tertiary level hospitals in Chile. Methods We conducted a prospective, multicenter, laboratory-based survey study of candidemia in 26 tertiary care hospitals in Chile, from January 2013 to October 2017. Results A total of 780 episodes of candidemia were included, with a median incidence of 0.47/1,000 admissions. Demographic, clinical and microbiological information of 384 cases of candidemia, from 18 hospitals (7,416 beds), was included in this report. One hundred and thirty-four episodes (35%) occurred in pediatric patients and 250 (65%) in adult population. Candida albicans (39%), Candida parapsilosis (30%) and Candida glabrata (10%) were the leading species, with a significant difference in the distribution of species between ages. The use of central venous catheter and antibiotics were the most frequent risk factors in all age groups (> 70%). Three hundred and fifteen strains were studied for antifungal susceptibility; 21 strains (6.6%) were resistant to fluconazole, itraconazole, voriconazole, anidulafungin or micafungin. The most commonly used antifungal therapies were fluconazole (39%) and echinocandins (36%). The overall 30-day survival was 74.2%, significantly higher in infants (82%) and children (86%) compared with neonates (72%), adults (71%) and elderly (70%). Conclusions Our prospective, multicenter surveillance study showed a low incidence of candidemia in Chile, with high 30-day survival, a large proportion of elderly patients, C. glabrata as the third most commonly identified strain, a 6.6% resistance to antifungal agents and a frequent use of echinocandins.es
dc.description.versionVersión Publicadaes
dc.identifier.citationSantolaya ME, Thompson L, Benadof D, Tapia C, Legarraga P, Corte´s C, et al. (2019) A prospective, multi-center study of Candida bloodstream infections in Chile. PLoS ONE 14(3): e0212924. https://doi.org/10.1371/journal. pone.0212924es
dc.identifier.urihttps://doi.org/10.1371/journal. pone.0212924es
dc.identifier.urihttp://hdl.handle.net/11447/6290
dc.language.isoenes
dc.relation.projectThis study was partially supported by FONDECYT, grant number 1161662, and partially supported by an independent medical grant from Pfizer Chile and from BioMerieux Chile.es
dc.titleA prospective, multi-center study of Candida bloodstream infections in Chilees
dc.typeArticlees
dcterms.sourcePlos Onees

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
pone.0212924.pdf
Size:
539.68 KB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services