Outcomes of Sepsis and Septic Shock in Cancer Patients: Focus on Lactate

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dc.contributor.authorLópez, René
dc.contributor.authorPérez-Araos, Rodrigo
dc.contributor.authorBaus, Fernanda
dc.contributor.authorMoscoso, Camila
dc.contributor.authorSalazar, Álvaro
dc.contributor.authorGraf, Jerónimo
dc.contributor.authorMontes, José Miguel
dc.contributor.authorSamtani, Suraj
dc.date.accessioned2022-03-25T18:44:00Z
dc.date.available2022-03-25T18:44:00Z
dc.date.issued2021
dc.description.abstractThe number of oncological patients (OP) admitted to intensive care units (ICU) for sepsis/septic shock has dramatically increased in recent years. The definition of septic shock has been modified, adding hyperlactatemia as a severity biomarker for mortality. However, it remains poorly reported in septic OP. We performed a retrospective analysis from a prospective database of sepsis/septic shock patients admitted to our ICU between September 2017 and September 2019 and followed until day 90. We identified 251 patients and 31.9% had active oncological comorbidity, mainly solid tumor (81.3%). Septic shock criteria were met for 112 (44.6%). Hyperlactatemia was observed in 136 (54.2%) patients and this was associated with a lower survival rate. Overall 90-day mortality was 15.1%. In OP vs. non-OP, hyperlactatemia was more frequent (65% vs. 49.1%, p = 0.013) and associated with lower survival (65.4% vs. 85.7%, p = 0.046). In OP, poor performance status was also associated with lower survival (HR 7.029 [1.998–24.731], p = 0.002) In an adjusted analysis, cancer was associated with lower 90-day survival (HR 2.690 [1.402–5.160], p = 0.003). In conclusion, septic OP remains a high mortality risk group in whom lactate levels and performance status could help with better risk stratification.es
dc.description.versionVersión publicadaes
dc.identifier.citationLópez R, Pérez-Araos R, Baus F, Moscoso C, Salazar Á, Graf J, Montes JM, Samtani S. Outcomes of Sepsis and Septic Shock in Cancer Patients: Focus on Lactate. Front Med (Lausanne). 2021 Apr 26;8:603275. doi: 10.3389/fmed.2021.603275. PMID: 33981712; PMCID: PMC8107210.es
dc.identifier.urihttps://doi.org/10.3389/fmed.2021.603275es
dc.identifier.urihttp://hdl.handle.net/11447/5805
dc.language.isoenes
dc.subjectcanceres
dc.subjectintensive care unies
dc.subjectseptic shockes
dc.subjectoncological patientes
dc.subjectcancer preventiones
dc.subjectcontroles
dc.titleOutcomes of Sepsis and Septic Shock in Cancer Patients: Focus on Lactatees
dc.typeArticlees
dcterms.sourceFrontiers in medicinees

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