Transferable vancomycin resistance in a community-associated MRSA lineage

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dc.contributor.authorRossi, Flávia
dc.contributor.authorDiaz, Lorena
dc.contributor.authorWollam, Aye
dc.contributor.authorPanesso, Diana
dc.contributor.authorZhou, Yanjiao
dc.contributor.authorRincon, Sandra
dc.contributor.authorNarechania, Apurva
dc.contributor.authorXing, Galen
dc.contributor.authorDi Gioia, Thais
dc.contributor.authorDoi, André
dc.contributor.authorTran, Truc
dc.contributor.authorReyes, Jinnethe
dc.contributor.authorMunita, José
dc.contributor.authorCarvajal, Lina
dc.contributor.authorHernandez-Roldan, Alejandra
dc.contributor.authorBrandão, Denise
dc.contributor.authorvan der Heijden, Inneke Marie
dc.contributor.authorMurray, Barbara
dc.contributor.authorPlanet, Paul
dc.contributor.authorWeinstock, George
dc.contributor.authorArias, Cesar
dc.date.accessioned2017-04-05T15:34:37Z
dc.date.available2017-04-05T15:34:37Z
dc.date.issued2014
dc.description.abstractWe report the case of a patient from Brazil with a bloodstream infection caused by a strain of methicillin-resistant Staphylococcus aureus (MRSA) that was susceptible to vancomycin (designated BR-VSSA) but that acquired the vanA gene cluster during antibiotic therapy and became resistant to vancomycin (designated BR-VRSA). Both strains belong to the sequence type (ST) 8 community-associated genetic lineage that carries the staphylococcal chromosomal cassette mec (SCCmec) type IVa and the S. aureus protein A gene (spa) type t292 and are phylogenetically related to MRSA lineage USA300. A conjugative plasmid of 55,706 bp (pBRZ01) carrying the vanA cluster was identified and readily transferred to other staphylococci. The pBRZ01 plasmid harbors DNA sequences that are typical of the plasmid-associated replication genes rep24 or rep21 described in community-associated MRSA strains from Australia (pWBG745). The presence and dissemination of community-associated MRSA containing vanA could become a serious public health concern.
dc.format.extent8
dc.identifier.citationN Engl J Med 2014; 370:1524-1531
dc.identifier.urihttp://hdl.handle.net/11447/1093
dc.identifier.urihttp://dx.doi.org/10.1056/NEJMoa1303359
dc.language.isoen_US
dc.publisherMassachusetts Medical Society
dc.subjectpublic health
dc.subjectbacterial infections
dc.subjectglobal health
dc.subjectgenetics
dc.titleTransferable vancomycin resistance in a community-associated MRSA lineage
dc.typeArtículo

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