Human seroepidemiology of Rickettsia and Orientia species in Chile – A crosssectional study in five regions

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dc.contributor.authorWeitzel, Thomas
dc.contributor.authorAcosta-Jamett, Gerardo
dc.contributor.authorJiang, Ju
dc.contributor.authorMartínez-Valdebenito, Constanza
dc.contributor.authorFarris, Christina M.
dc.contributor.authorRichards, Allen L.
dc.contributor.authorAbarca, Katia
dc.date.accessioned2021-08-13T16:17:10Z
dc.date.available2021-08-13T16:17:10Z
dc.date.issued2020
dc.description.abstractIn recent years, the spectrum and epidemiology of human rickettsioses has become an emerging topic in Chile. This survey aimed to assess the seroprevalence of spotted fever group rickettsiae (SFGR), typhus group rickettsiae (TGR), and scrub typhus group orientiae (STGO) in northern, central, and southern Chile. We performed a cross-sectional study of healthy adults in rural and urban settings of five regions. Participants were chosen by double stratified random sampling in urban and by convenience in rural locations (n = 1302). Serum specimens were analyzed for group-specific IgG antibodies against SFGR, TGR, and STGO by enzyme-linked immunosorbent assays (ELISAs). Overall seroprevalences to SFGR, TGR, and STGO were 5.3 %, 1.2 %, and 0.4 %, respectively. Prevalences showed geographical differences. Statistical analyses revealed an association of older age with seropositivity to SFGR and to TGR and of rural setting and male gender with seropositivity to SFGR. The study indicates that SFGR, TGR, and STGO are endemic in Chile. The very low STGO seroprevalence might indicate an insufficient sensitivity of serological tests using Asian O. tsutsugamushi strains as ELISA antigens for the detection of antibodies against Chilean Orientia species.es
dc.identifier.citationTicks and Tick-borne Diseases, 2020, vol.11:101503es
dc.identifier.urihttps://doi.org/10.1016/j.ttbdis.2020.101503es
dc.identifier.urihttp://hdl.handle.net/11447/4300
dc.language.isoenes
dc.subjectVector-borne diseaseses
dc.subjectRickettsiaes
dc.subjectOrientiaes
dc.subjectEpidemiologyes
dc.subjectSeroprevalencees
dc.titleHuman seroepidemiology of Rickettsia and Orientia species in Chile – A crosssectional study in five regionses
dc.typeArticlees

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