LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement
| dc.contributor.author | Vernuccio, Federica | |
| dc.contributor.author | Cannella, Roberto | |
| dc.contributor.author | Meyer, Mathias | |
| dc.contributor.author | Choudhoury, Kingshuk Roy | |
| dc.contributor.author | González, Fernando | |
| dc.contributor.author | Schwartz, Fides R. | |
| dc.contributor.author | Gupta, Rajan T. | |
| dc.contributor.author | Bashir, Mustafa R. | |
| dc.contributor.author | Furlan, Alessandro | |
| dc.contributor.author | Marin, Daniele | |
| dc.date.accessioned | 2022-07-21T17:23:26Z | |
| dc.date.available | 2022-07-21T17:23:26Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | OBJECTIVE. The purpose of this study was to determine the diagnostic performance of hepatobiliary phase hypointensity and Liver Imaging Reporting and Data System (LI-RADS) major imaging features in the diagnosis of hepatocellular carcinoma (HCC) in hepatic lesions with arterial phase hyperenhancement (APHE) measuring 10-19 mm in patients at high risk of HCC. MATERIALS AND METHODS. A composite reference standard of pathologic analysis and imaging follow-up was used. The diagnostic performance (sensitivity and specificity) of hepatobiliary phase hypointensity and LI-RADS major imaging features other than APHE for the diagnosis of HCC was assessed and compared by means of a logistic regression model. RESULTS. This retrospective dual-institution study included 189 LI-RADS LR-3 and LR-4 lesions measuring 10-19 mm and having APHE in 144 consecutively registered patients (96 men, 48 women; mean age, 58 years). Hepatobiliary phase hypointensity had significantly higher sensitivity (84% [92/109], p < 0.00001) than major imaging features in the diagnosis of HCC but lower specificity (84% [67/80]; p = 0.01). However, hepatobiliary phase hypointensity in LR-3 observations measuring 10-19 mm and having APHE had moderately elevated sensitivity (73% [44/60]) and specificity (85%, 64/75). All three major imaging features had high specificity for the diagnosis of HCC, including 95% (76/80) for washout, 100% (80/80) for enhancing capsule, and 99% (79/80) for threshold growth. CONCLUSION. Major imaging features have high specificity for the diagnosis of HCC in lesions measuring 10-19 mm that have APHE. The finding of hepatobiliary phase hypointensity significantly improves sensitivity while moderately high specificity is maintained for the diagnosis of HCC in LR-3 lesions measuring 10-19 mm that exhibit APHE. | es |
| dc.description.version | Versión Publicada | es |
| dc.identifier.citation | Vernuccio F, Cannella R, Meyer M, Choudhoury KR, Gonzáles F, Schwartz FR, Gupta RT, Bashir MR, Furlan A, Marin D. LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement. AJR Am J Roentgenol. 2019 Aug;213(2):W57-W65. doi: 10.2214/AJR.18.20979. | es |
| dc.identifier.uri | http://doi.org/10.2214/AJR.18.20979 | es |
| dc.identifier.uri | http://hdl.handle.net/11447/6378 | |
| dc.language.iso | en | es |
| dc.subject | MRI | es |
| dc.subject | Cirrhosis | es |
| dc.subject | Gadoxetate disodium | es |
| dc.subject | Gadoxetic acid | es |
| dc.subject | Hepatocellular carcinoma | es |
| dc.subject | Liver | es |
| dc.subject | Sensitivity | es |
| dc.subject | Specificity | es |
| dc.title | LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement | es |
| dc.type | Article | es |
| dcterms.source | American Journal of Roentgenology | es |