Ineffective esophageal motility and bolus clearance. A study with combined high-resolution manometry and impedance in asymptomatic controls and patients

Simple item page
dc.contributor.authorZerbib, Frank
dc.contributor.authorMarin, Ingrid
dc.contributor.authorCisternas, Daniel
dc.contributor.authorAbrahao Jr, Luiz
dc.contributor.authorHani, Albis
dc.contributor.authorLeguizamo, Ana M.
dc.contributor.authorRemes-Troche, José M.
dc.contributor.authorPerez de la Serna, Julio
dc.contributor.authorRuiz de Leon, Antonio
dc.contributor.authorSerra, Jordi
dc.date.accessioned2021-10-28T15:29:34Z
dc.date.available2021-10-28T15:29:34Z
dc.date.issued2020
dc.description.abstractBackground The definition and relevance of ineffective esophageal motility (IEM) remains debated. Our aim was to determine motility patterns and symptoms associated with IEM defined as impaired bolus clearance. Methods To define altered bolus clearance, normal range of swallows with complete bolus transit (CBT) on high-resolution impedance manometry (HRIM) was determined in 44 asymptomatic controls. The results were then applied to a cohort of 81 patients with esophageal symptoms to determine the motility patterns which best predicted altered bolus clearance. Subsequently, in a cohort of 281 consecutive patients the identified motility patterns were compared with patients’ customary symptoms. Key Results In asymptomatic controls, the normal range of swallows with CBT was 50%-100%. In patients, altered bolus transit (<50% CBT) was only associated with 30% or more failed contractions (P < .001). Neither weak peristalsis nor absence of contraction reserve (CR) was associated with altered bolus clearance. The patterns which best predicted altered bolus clearance were failed contractions ≥30% (specificity 88.2% and sensitivity of 84.6%), and ≥70% ineffective (failed + weak) contractions (sensitivity 84.6% and specificity 80.9%). No motility pattern was correlated to symptom scores. Conclusions and Inferences Based on bolus clearance assessed by HRIM, ≥30% failed contractions and ≥70% ineffective contractions have the best sensitivity and specificity to predict altered bolus clearance. Weak contractions and absence of CR are not relevant with respect to bolus clearance.es
dc.identifier.citationNeurogastroenterology & Motility. 2020;32:e13876es
dc.identifier.urihttps://doi.org/10.1111/nmo.13876es
dc.identifier.urihttp://hdl.handle.net/11447/4969
dc.language.isoen_USes
dc.subjectesophageal bolus clearancees
dc.subjectesophageal motilityes
dc.subjecthigh-resolution esophageal manometryes
dc.titleIneffective esophageal motility and bolus clearance. A study with combined high-resolution manometry and impedance in asymptomatic controls and patientses
dc.typeArticlees

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ineffective esophageal motility and bolus clearance. A study with combined high-resolution manometry and impedance in asymptomatic controls and patients.pdf
Size:
941.29 KB
Format:
Adobe Portable Document Format
Description:
Texto Completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services