Specificities of ischemic stroke risk factors in arab-speaking countries

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dc.contributor.authorOPTIC Registry and PERFORM Trial Investigators
dc.contributor.authorAbboud, Halim
dc.contributor.authorSissani, L
dc.contributor.authorLabreuche, J
dc.contributor.authorArauz, Antonio
dc.contributor.authorBousser, M
dc.contributor.authorBryer, A
dc.contributor.authorChamorro, A
dc.contributor.authorFisher, M
dc.contributor.authorFord, I
dc.contributor.authorFox, K
dc.contributor.authorHennerici, M
dc.contributor.authorLavados, Pablo
dc.contributor.authorMassaro, A
dc.contributor.authorMattle, Heinrich
dc.contributor.authorMunoz Collazos, M
dc.contributor.authorRothwell, P
dc.contributor.authorSteg, P
dc.contributor.authorVicaut, E
dc.contributor.authorYamouth, B
dc.contributor.authorAmarenco, Pierre
dc.date.accessioned2017-09-11T16:38:27Z
dc.date.available2017-09-11T16:38:27Z
dc.date.issued2017
dc.description.abstractBackground: Stroke is largely preventable, and therefore, a better understanding of risk factors is an essential step in reducing the population stroke rate and resulting disease burden in Arab countries. Summary: We performed 2 separate analyses in 2 similar populations of patients with noncardioembolic ischemic stroke. This first involved 3,635 patients in the Outcomes in Patients with TIA and Cerebrovascular disease (OPTIC) registry (followed for 2 years), with baseline collection of the usual risk factors and 5 socioeconomic variables (unemployment status, residence in rural area, living in fully serviced accommodation, no health-insurance coverage, and low educational level). The second involved patients in the PERFORM trial (n = 19,100 followed up for 2 years), with baseline collection of the usual risk factors and 1 socioeconomic variable (low educational level). The primary outcome was a composite of nonfatal stroke, nonfatal myocardial infarction, or cardiovascular death. Stroke risk factors were more prevalent in patients in Arab countries. The incidence of major cardiovascular events (MACE; age- and gender-adjusted) was higher in Arab countries (OPTIC, 18.5 vs. 13.3%; PERFORM, 18.4 vs. 9.7%; both p ≤ 0.0001). These results remained significant after adjustment on risk factors and were attenuated in OPTIC after further adjustment on socioeconomic variables (hazard ratio 1.24; 95% CI 0.98-1.55; p = 0.07). Key Messages: Patients with ischemic stroke living in Arab countries had a lower mean socioeconomic status, a much higher prevalence of diabetes mellitus, and a higher rate of MACE compared with patients from non-Arab countries. This finding is partly explained by a higher prevalence of risk factors and also by a high prevalence of poverty and low educational level.
dc.description.versionVersión Publicada
dc.format.extent9
dc.identifier.citationAbboud H, Sissani L, Labreuche J, Arauz A, Bousser MG, Bryer A, Chamorro A, Fisher M, Ford I, Fox KM, Hennerici MG, Lavados PM, Massaro A, Mattle HP, Munoz Collazos M, Rothwell PM, Steg PG, Vicaut E, Yamouth B, Amarenco P; OPTIC Registry and PERFORM Trial Investigators. Specificities of Ischemic Stroke Risk Factors in Arab-Speaking Countries. Cerebrovasc Dis. 2017;43(3-4):169-177. doi: 10.1159/000454776.
dc.identifier.urihttp://hdl.handle.net/11447/1670
dc.identifier.urihttp://dx.doi.org/10.1159/000454776
dc.language.isoen_US
dc.publisherKarger
dc.sourceCerebrovascular Diseases
dc.subjectTIA
dc.subjectRisk factors
dc.subjectsocio-economic status
dc.subjectstroke
dc.titleSpecificities of ischemic stroke risk factors in arab-speaking countries
dc.typeArtículo

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