Infección por Helicobacter pylori en pacientes sintomáticos con patología gastroduodenal benigna. Análisis de 5.664 pacientes

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dc.contributor.authorROLLÁN, ANTONIO
dc.contributor.authorRIQUELME, ARNOLDO
dc.contributor.authorPADILLA, OSLANDO
dc.contributor.authorVILLARROEL, LUIS
dc.contributor.authorNILSEN, EVA
dc.contributor.authorPRUYAS, MARTHA
dc.contributor.authorVERDUGO, PATRICIA
dc.contributor.authorCALVO, ALFONSO
dc.contributor.authorEspino, Alberto
dc.contributor.authorORTEGA, JUAN PABLO
dc.date.accessioned2021-09-22T14:59:56Z
dc.date.available2021-09-22T14:59:56Z
dc.date.issued2010
dc.description.abstractInfection with Helicobacter pylori (H. pylori) is highly prevalent in Chile, but there are no systematic studies in patients with upper gastrointestinal symptoms. Aim: To determine the prevalence of H. pylori infection, according to age, gender and endoscopic pathology in a large sample of patients. Methods: We studied 7,893 symptomatic patients submitted to upper gastrointestinal endoscopy between July 1996 and December 2003 in the context of a screening program of gastric cancer in a high risk population. H. pylori infection was determined by rapid urease test (RUT) in antral mucosa. We excluded 158 patients with gastric cancer (2%) and 2,071 patients without RUT. Results: We included 5,664 patients, mean age 50.7 ± 13.9 years, women 72.1%. Endoscopic diagnoses were normal in 59.3%, erosive esophagitis in 20%, gastric ulcer (GU) in 8.1%, duodenal ulcer (DU) in 6.4%, and erosive gastropathy in 6.2%. RUT was positive in 78% of patients. After adjusting for age and sex and with respect to patients with normal endoscopy, frequency of H. pylori infection was 86.6% in DU (OR 2.1, 95% CI 1.5-2.8, p < 0.001); 81.4% in GU (OR 1.8, 95% CI 1.4-2.4; p < 0.001 ); 79.9% in erosive gastropathy (OR 1.4, 95% CI 1.03-1.8; p = 0.03) and 77.4% in erosive esophagitis (OR 1.1, 95% CI: 0.9-1.3; p = NS). The probability of H. pylori infection decreased significantly with age, more markedly in men with normal endoscopy. Conclusions: Prevalence of H. pylori infection is very high in symptomatic Chilean patients and even higher in those with gastroduodenal ulcer or erosions, while in patients with erosive esophagitis is similar to those with normal endoscopy. The frequency of infection decreases with age, probably as a consequence of rising frequency of gastric mucosal atrophyes
dc.identifier.citationRevista Medica Chilena 2010; 138: 529-535es
dc.identifier.urihttp://dx.doi.org/10.4067/S0034-98872010000500001es
dc.identifier.urihttp://hdl.handle.net/11447/4676
dc.language.isoeses
dc.subjectHelicobacter pylories
dc.subjectEpidemiologyes
dc.subjectPeptic ulceres
dc.subjectGastroscopyes
dc.titleInfección por Helicobacter pylori en pacientes sintomáticos con patología gastroduodenal benigna. Análisis de 5.664 pacienteses
dc.title.alternativeHelicobacter pylori infection in symptomatic patients with benign gastroduodenal diseases. Analysis of 5.664 caseses
dc.typeArticlees

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