Cancer History Is Associated with Slower Speed of Cognitive Decline in Patients with Amnestic Cognitive Impairment

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dc.contributor.authorCastillo, Rolando
dc.contributor.authorVergara, Rodrigo
dc.contributor.authorRogers, Nicole
dc.contributor.authorPonce, Daniela
dc.contributor.authorBennett, Magdalena
dc.contributor.authorBehrens, María
dc.date.accessioned2022-10-12T15:11:36Z
dc.date.available2022-10-12T15:11:36Z
dc.date.issued2022
dc.description.abstractBackground: Several epidemiological studies report a negative association between Cancer and Alzheimer's disease (AD). Objective: To characterize the trajectories of memory loss in individuals with early amnestic cognitive impairment with and without history of previous cancer. Methods: Cognitive deterioration was assessed using the Montreal Cognitive Assessment (MoCA) or MoCA-Memory Index Score (MoCA-MIS) biannually in subjects with early amnestic cognitive impairment followed-up retrospectively from 2007 to 2021. History of Cancer was obtained from clinical records. Simple linear regressions of MoCA-MIS scores were calculated for each subject and analyzed with K-means cluster analysis to identify subgroups with different cognitive decline trajectories. χ2 and t tests were used for descriptive categorical and continuous variables and mixed multiple linear regressions to determine cognitive decline covariates. Results: Analysis of the trajectory of cognitive decline in 141 subjects with early amnestic cognitive impairment identified two subgroups: Fast (n = 60) and Slow (n = 81) progressors. At baseline Fast progressors had better MoCA-MIS (p < 0.001) and functionality (CDR p = 0.02, AD8 p = 0.05), took less anti-dementia medications (p = 0.005), and had higher depression rates (p = 0.02). Interestingly, Fast progressors slowed their speed of memory decline (from 1.6 to 1.1 MoCA-MIS points/year) and global cognitive decline (from 2.0 to 1.4 total MoCA points/year) when Cancer history was present. Conclusion: Two trajectories of amnestic cognitive decline were identified, possibly derived from different neurophysiopathologies or clinical stages. This study suggests that a history of previous Cancer slows down amnestic cognitive decline, specifically in a subgroup of subjects with depression at baseline and accelerated deterioration at follow-up.es
dc.description.versionVersión aceptadaes
dc.identifier.citationCastillo-Passi RI, Vergara RC, Rogers NK, Ponce DP, Bennett M, Behrens MI. Cancer History Is Associated with Slower Speed of Cognitive Decline in Patients with Amnestic Cognitive Impairment. J Alzheimers Dis. 2022;87(4):1695-1711. doi: 10.3233/JAD-215660es
dc.identifier.urihttps://doi.org/doi:10.3233/JAD-215660es
dc.identifier.urihttp://hdl.handle.net/11447/6599
dc.language.isoenes
dc.subjectAlzheimer’s diseasees
dc.subjectCancer historyes
dc.subjectCognitive declinees
dc.subjectMemoryes
dc.subjectMild cognitive impairment.es
dc.titleCancer History Is Associated with Slower Speed of Cognitive Decline in Patients with Amnestic Cognitive Impairmentes
dc.typeArticlees
dcterms.sourceJournal of Alzheimer's disease : JADes

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