A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression

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dc.contributor.authorAltinbas, Kursat
dc.contributor.authorOzerdem, Aysegul
dc.contributor.authorPrieto, Miguel
dc.contributor.authorFuentes, Manuel
dc.contributor.authorYalin, Nefize
dc.contributor.authorErsoy, Zeliha
dc.contributor.authorAydemir, Omer
dc.contributor.authorQuiroz, Danilo
dc.contributor.authorOztekin, Signem
dc.contributor.authorGeske, Jennifer
dc.contributor.authorFeeder, Scott
dc.date.accessioned2017-03-20T19:45:16Z
dc.date.available2017-03-20T19:45:16Z
dc.date.issued2014
dc.description.abstractBACKGROUND: Mixed depression is a common, dimensional phenomenon that is increasingly recognized in unipolar and bipolar disorders. We piloted a modified version of the Hypomania Checklist (mHCL-32) to assess the prevalence and clinical correlates of concurrent manic (hypo) symptoms in depressed patients. METHODS: The mHCL-32, Young Mania Rating Scale (YMRS) and Hamilton Rating Scale for Depression (HAMD-24) were utilized in the assessment of unipolar (UP=61) and bipolar (BP=44) patients with an index major depressive episode confirmed by the Structured Clinical Interview for DSM-IV (SCID). Differential mHLC-32 item endorsement was compared between UP and BP. Correlation analyses assessed the association of symptom dimensions measured by mHCL-32, YMRS and HAMD-24. RESULTS: There was no significant difference between mood groups in the mean mHCL-32 and YMRS scores. Individual mHLC-32 items of increased libido, quarrels, and caffeine intake were endorsed more in BP vs. UP patients. The mHCL-32 active-elevated subscale score was positively correlated with the YMRS in BP patients and negatively correlated with HAMD-24 in UP patients. Conversely, the mHCL-32 irritable-risk taking subscale score was positively correlated with HAMD-24 in BP and with YMRS in UP patients. LIMITATIONS: Small sample size and cross-sectional design. CONCLUSION: Modifying the HCL to screen for (hypo) manic symptoms in major depression may have utility in identifying mixed symptoms in both bipolar vs. unipolar depression. Further research is encouraged to quantify mixed symptoms with standardized assessments.
dc.format.extent5
dc.identifier.citationJ Affect Disord. 2014 Jan;152-154 p:478-482
dc.identifier.urihttp://hdl.handle.net/11447/1043
dc.identifier.urihttp://dx.doi.org/10.1016/j.jad.2013.07.032
dc.language.isoen_US
dc.publisherElsevier
dc.subjectBipolar
dc.subjectDepression
dc.subjectModified hypomania checklist
dc.subjectUnipolar
dc.titleA multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression
dc.typeArtículo

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