Resistance to last resort antibiotics in gram-positive cocci: the post-vancomycin era

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dc.contributor.authorRincon, Sandra
dc.contributor.authorPanesso, Diana
dc.contributor.authorDiaz, Lorena
dc.contributor.authorCarvajal, Lina
dc.contributor.authorReyes, Jinnethe
dc.contributor.authorMunita, José
dc.contributor.authorArias, Cesar
dc.date.accessioned2017-04-05T15:16:44Z
dc.date.available2017-04-05T15:16:44Z
dc.date.issued2014
dc.description.abstractNew therapeutic alternatives have been developed in the last years for the treatment of multidrug-resistant Gram-positive infections. Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) are considered a therapeutic challenge due to failures and lack of reliable antimicrobial options. Despite concerns related to the use of vancomycin in the treatment of severe MRSA infections in specific clinical scenarios, there is a paucity of solid clinical evidence that support the use of alternative agents (when compared to vancomycin). Linezolid, daptomycin and tigecycline are antibiotics approved in the last decade and newer cephalosporins (such as ceftaroline and ceftobiprole) and novel glycopeptides (dalvavancin, telavancin and oritavancin) have reached clinical approval or are in the late stages of clinical development. This review focuses on discussing these newer antibiotics used in the "post-vancomycin" era with emphasis on relevant chemical characteristics, spectrum of antimicrobial activity, mechanisms of action and resistance, as well as their clinical utility.
dc.format.extent25
dc.identifier.citationBiomedica. 2014 Apr;34 Suppl 1:191-208
dc.identifier.urihttp://hdl.handle.net/11447/1092
dc.identifier.urihttp://dx.doi.org/10.1590/S0120-41572014000500022
dc.language.isoen_US
dc.publisherInstituto Nacional de Salud de Colombia
dc.subjectcomplementary therapies
dc.subjectgram-positive bacterias
dc.subjectdrug resistance
dc.subjectmicrobial
dc.subjectvancomycin
dc.subjectdaptomycin
dc.subjectcephalosporins
dc.titleResistance to last resort antibiotics in gram-positive cocci: the post-vancomycin era
dc.typeArtículo

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